- Catalog numberbs-1879R-A555
- Product namePSAP Antibody, ALEXA FLUOR 555
- Size100ul
- PriceAsk For Price
- Short nameAnti-PSAP/PAP
- Long namePSAP Polyclonal Antibody, ALEXA FLUOR 555 Conjugated
- Also known asAnti-PSAP/PAP PAb ALEXA FLUOR 555
- CategoryConjugated Primary Antibodies
- Conjugated withALEXA FLUOR® 555
- Host OrganismRabbit (Oryctolagus cuniculus)
- Target AntigenPSAP/PAP
- SpecificityThis is a highly specific antibody against PSAP/PAP.
- ModificationUnmodified
- Modification SiteNone
- ClonalityPolyclonal
- ClonePolyclonal antibody
- IsotypeImmunoglobulin G (IgG)
- Concentration1ug per 1ul
- Immunogen range144-194/524
- Subcellular locationSecreted
- SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human PSAP
- Gene ID Number5660
- Swiss ProtP07602
- Tested applicationsIF(IHC-P)
- Recommended dilutionsIF(IHC-P)(1:50-200)
- CrossreactivityHuman
- Cross reactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
- Background of the antigenSaposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase (EC 3.2.1.46). Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate. Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A (EC 3.1.6.8), GM1 gangliosides by beta-galactosidase (EC 3.2.1.23) and globotriaosylceramide by alpha-galactosidase A (EC 3.2.1.22). Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases. Saposin-D is a specific sphingomyelin phosphodiesterase activator (EC 3.1.4.12). Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases.
- PurificationPurified by Protein A.
- Storage conditionsStore this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
- Excitation emission553nm/568nm
- SynonymsGLBA; SAP1; Prosaposin; Proactivator polypeptide; PSAP
- Gene targetPSAP
- Identity:HGNC:9498
- Gene:PSAP
- Long gene name:prosaposin
- Synonyms gene name:sphingolipid activator protein-1, sphingolipid activator protein-2
- Discovery year:1986-01-01
- Entrez gene record:5660
- Pubmed identification:2717620
- RefSeq identity:NM_002778
- Classification:Receptor ligands
- VEGA ID:OTTHUMG00000018429
- Identity:HGNC:17586
- Gene:MTCH1
- Long gene name:mitochondrial carrier 1
- Synonyms gene name:mitochondrial carrier homolog 1 (C. elegans)
- Synonyms:CGI-64PSAPSLC25A49
- Discovery year:2003-05-20
- Entrez gene record:23787
- Pubmed identification:12377771
- RefSeq identity:NM_014341
- Classification:Solute carriers
- VEGA ID:OTTHUMG00000014614
- Gene symbolPSAP, MTCH1
- isotype filter
- Immunoglobulin G IgG
- LabelALEXA FLUOR 555
- label filter
- ALEXA FLUOR 555
- technique filter
- Antibody
- TechniqueAntibody, antibodies against human proteins, antibodies for
- Alternative techniqueantibodies