Legionella pneumophila LPS antibody
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Catalog number10-L105A
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PricePlease ask
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Size1 mg
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CategoryPrimary Antibody
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Antibody SubtypeMonoclonal Antibodies
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Area of researchInfectious Disease
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Type of ImmunogenLegionella pneumophila LPS antibodies were raised in mouse using membrane fraction of Legionella pneumophila (Philadelphia strain) ..
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Raised inMouse
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SpecificityReacts with LPS membrane of Legionella pneumophila
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Cross ReactivityDoes not crossreact with Legionella pneumophila serogroups 2, 6, 7, 10 and 11, Legionella bozemanii, Legionella lonbeachae, Corynebacterium diphtheria, Bordetella pertusis, Leptospira interrogens (Australia, Pomona, Icterogemorrhagia), Pseudomonas fluorescens, Legionella micdadei, Pseudomonas cepacia, Pseudomonas aerugenose, Toxoplasma gondii, Hemophilus influenza (type B), Hemophilus ducreyi, Brucella abortus, Bacillus anthracis, Klebsiella pneumoniae, Listeria monocytogenes, Mycobacterium tuberculosis, Neisseria meningitides, Pasteurella multocida, Proteus vulgaris, Shigella sonnei, Staphylocccus faecalis, Streptococcus puogenes, Streptococcus pneumoniae, Yersinia pseudotuberculosis, Yersinia pestis EV76, Salmonella typhi, Escherichia coli K88 and Francisella tularensis 15. Crossreaction with Legionella pneumophila serogroups 3 and 4 has not been tested.
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IsotypesIgG3
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CloneM12619LP
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Method of PurificationLegionella pneumophila LPS antibody was purified by Protein G chromatography.
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Form BufferProvided in PBS, pH 7.4, 0.1 % NaN3 (NaN3)
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StorageStore at 4 Deg C
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Shipping conditionsBlue Ice
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Tested forELISA; Immunoassays
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Assay Information10-L105A can be used in a sandwich immunoassay as a conjugate antibody in conjunction with 10-7870 as the coating antibody
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PropertiesIf you buy Antibodies supplied by fitzgerald they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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GeneBacterial pathogen lipopolysaccharides (LPS) are the major outer surface membrane components present in almost all Gram-negative bacteria and act as extremely strong stimulators of innate or natural immunity in diverse eukaryotic species ranging from insects to humans. LPS consist of a poly- or oligosaccharide region that is anchored in the outer bacterial membrane by a specific carbohydrate lipid moiety termed lipid A. The lipid A component is the primary immunostimulatory center of LPS. With respect to immunoactivation in mammalian systems, the classical group of strongly agonistic (highly endotoxin) forms of LPS has been shown to be comprised of a rather similar set of lipid A types. In addition, several natural or derivative lipid A structures have been identified that display comparatively low or even no immunostimulation for a given mammalian species. Some members of the latter more heterogeneous group are capable of antagonizing the effects of strongly stimulatory LPS/lipid A forms. Agonistic forms of LPS or lipid A trigger numerous physiological immunostimulatory effects in mammalian organisms, but--in higher doses--can also lead to pathological reactions such as the induction of septic shock. Cells of the myeloid lineage have been shown to be the primary cellular sensors for LPS in the mammalian immune system. During the past decade, enormous progress has been obtained in the elucidation of the central LPS/lipid A recognition and signaling system in mammalian phagocytes. According to the current model, the specific cellular recognition of agonistic LPS/lipid A is initialized by the combined extracellular actions of LPS binding protein (LBP), the membrane-bound or soluble forms of CD14 and the newly identified Toll-like receptor 4 (TLR4)*MD-2 complex, leading to the rapid activation of an intracellular signaling network that is highly homologous to the signaling systems of IL-1 and IL-18. The elucidation of structure-activity correlations in LPS and lipid A has not only contributed to a molecular understanding of both immunostimulatory and toxic septic processes, but has also re-animated the development of new pharmacological and immuno-stimulatory strategies for the prevention and therapy of infectious and malignant diseases.
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French translationanticorps
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Gene target
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Gene symbolIRF6
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Short nameLegionella pneumophila LPS antibody
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TechniqueAntibody, antibodies against human proteins, antibodies for
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Alternative nameMouse monoclonal Legionella pneumophila LPS antibody
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Alternative techniqueantibodies
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Diseaselegionella
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Gene info
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Identity
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Gene
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Long gene nameinterferon regulatory factor 6
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Synonyms gene
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Synonyms gene name
- Van der Woude syndrome
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Synonyms
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GenBank acession
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Locus
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Discovery year1997-10-16
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Interferon regulatory factors
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data