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HIV protease monoclonal antibody

  • Catalog number
    12-302-C100
  • Product name
    HIV protease monoclonal antibody
  • Size
    100ug
  • Short name
    Anti-HIV protease Mab
  • Long name
    Mouse Monoclonal Antibody against HIV HIV protease, Clone: 1696
  • Antigen
    HIV protease
  • Host
    Mouse (Mus musculus)
  • Species reactivity
    HIV
  • Negative species reactivity
    at the time of upload there has been no data, please, contact us to obtain most recent information on species reactivity and cross reactivity
  • Clonality
    Monoclonal Antibody (Mab)
  • Clone
    1696
  • Isotype
    IgG1
  • Applications
    WB, ELISA, FUNC
  • Immunogen
    Bacterially expressed full-length HIV-1 protease
  • Format conjugation
    low endotoxin, unconjugated
  • Specificity
    The antibody 1696 recognizes free N-terminus of mature HIV protease (HIV-1 and HIV-2), an enzyme that hydrolyzes polyproteins of HIV viruses into functional proteins. The antibody 1696 does not react with the precursor.
  • Research area
    Virology and Microbiology
  • Concentration
    1 mg/ml
  • Storage buffer
    Azide free phosphate buffered saline (PBS), approx. pH 7.4; 0.2 μm filter sterilized. Endotoxin level is less than 0.01 EU/μg of the protein, as determined by the LAL test.
  • Shipping and storage
    Mouse Monoclonal Antibody against HIV HIV protease, Clone: 1696 is transported on blue ice/ice packs and should be stored at temperatures between 1 and 5 degrees Celsius. Do not freeze! Avoid exposing the product to direct light, especially the conjugated antibodies as most conjugates are very sentitive to light.
  • Background
    The HIV protease (PR) hydrolyzes polyproteins of HIV virus into functional protein products that are essential for its assembly and subsequent activity. This maturation process occurs as the virion buds from the host cell. HIV protease inhibitors are used in the treatment of patients with AIDS and were considered the first breakthrough in over a decade of AIDS research. HIV protease inhibitors can lower the viral load carried by AIDS patents. _x000D_
  • Purity
    > 95% (by SDS-PAGE)
  • Purification method
    Purified by protein-A affinity chromatography
  • Datasheet
    Datasheet
  • References
    *Bartonová V, Král V, Sieglová I, Brynda J, Fábry M, Horejsí M, Kozísek M, Sasková KG, Konvalinka J, Sedlácek J, Rezácová P: Potent inhibition of drug-resistant HIV protease variants by monoclonal_x000D_ antibodies. Antiviral Res. 2008 Jun;78(3):275-7. Epub 2008 Feb 20._x000D_ _x000D_ _x000D_ , *Lescar J, Brynda J, Rezacova P, Stouracova R, Riottot MM, Chitarra V, Fabry M, Horejsi M, Sedlacek J, Bentley GA: Inhibition of the HIV-1 and HIV-2 proteases by a monoclonal antibody. Protein Sci. 1999 Dec;8(12):2686-96. _x000D_ , *O'Loughlin TL, Greene DN, Matsumura I: Diversification and specialization of HIV protease function during in vitro evolution. Mol Biol Evol. 2006 Apr;23(4):764-72. _x000D_
  • Gene target
    HIV protease monoclonal
    • Gene info
  • Gene symbol
    HIVEP2
  • isotype filter
    • IgG1
  • technique filter
    • Antibody
  • Technique
    Antibody, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies
  • Alternative technique
    antibodies
  • Virus
    hiv
  • virus filter
    • hiv