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CD83 monoclonal antibody

  • Catalog number
    11-677-C100
  • Product name
    CD83 monoclonal antibody
  • Size
    100ug
  • Short name
    Anti-CD83 Mab
  • Long name
    Mouse Monoclonal Antibody against Human CD83, Clone: HB15e
  • Antigen
    CD83
  • Host
    Mouse (Mus musculus)
  • Species reactivity
    Human (Homo sapiens), Non-Human (Homo sapiens) Primates
  • Negative species reactivity
    at the time of upload there has been no data, please, contact us to obtain most recent information on species reactivity and cross reactivity
  • Clonality
    Monoclonal Antibody (Mab)
  • Clone
    HB15e
  • Isotype
    IgG1
  • Applications
    FC, IHC(F)
  • Immunogen
    Human CD83-transfected Cos cells
  • Format conjugation
    purified; unconjugated
  • Specificity
    The mouse monoclonal antibody HB15e recognizes CD83, a 40-45 kDa type I glycoprotein expressed on mature dendritic cells. _x000D_ HLDA IV.; WS Code T 85
  • Research area
    CD Antigens & MHC (Veterinary), CD and Related Antigens (Human)
  • Concentration
    1 mg/ml
  • Storage buffer
    Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
  • Shipping and storage
    Mouse Monoclonal Antibody against Human CD83, Clone: HB15e is transported on blue ice/ice packs and should be stored at temperatures between 1 and 5 degrees Celsius. Do not freeze! Avoid exposing the product to direct light, especially the conjugated antibodies as most conjugates are very sentitive to light.
  • Background
    CD83 is a 40-45 kDa heavily glycosylated type I cell surface glycoprotein of immunoglobulin family. It is expressed on the surface of mature dendritic cells, Langerhans cells in the skin, and interdigitating reticulum cells in the lymphoid tissues. Low expression of CD83 has been reported in activated T and B cells. Cytoplasmic expression of CD83 can be detected also in monocytes and macrophages. CD83 is involved in modulation of antigen presentation. Soluble CD83 has immunoregulatory functions, it is able to down-regulate dendritic cell maturation and stimulation of T cells. In the developing immune system, release of soluble CD83 from dendritic cells upon stimulation by gram-positive or gram-negative bacteria has anti-allergic effect. Herpes simplex virus, on the other hand, causes CD83 degradation in mature dendritic cells.
  • Purity
    > 95% (by SDS-PAGE)
  • Purification method
    Purified by protein-A affinity chromatography
  • Datasheet
    Datasheet
  • References
    Contact us for the most recent list of references
  • Alternative to gene target
    • [ "CD83 molecule", "BL11 and HB15", "CD83 and IDBG-62750 and ENSG00000112149 and 9308", "protein binding", "Cell surfaces", "Cd83 and IDBG-147707 and ENSMUSG00000015396 and 12522", "CD83 and IDBG-636028 and ENSBTAG00000031430 and 617034" ]
  • Gene target
    CD83 monoclonal
    • Gene info
  • Gene symbol
    CD83
  • isotype filter
    • IgG1
  • technique filter
    • Antibody
  • Technique
    Antibody, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies
  • Alternative technique
    antibodies