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CD7 monoclonal antibody

  • Catalog number
    1F-206-T100
  • Product name
    CD7 monoclonal antibody
  • Size
    100 assays
  • Short name
    Anti-CD7 Mab
  • Long name
    Mouse Monoclonal Antibody against Human CD7, Clone: MEM-186
  • Antigen
    CD7
  • Host
    Mouse (Mus musculus)
  • Species reactivity
    Human (Homo sapiens)
  • Negative species reactivity
    at the time of upload there has been no data, please, contact us to obtain most recent information on species reactivity and cross reactivity
  • Clonality
    Monoclonal Antibody (Mab)
  • Clone
    MEM-186
  • Isotype
    IgG1
  • Applications
    FC, IP, WB, IHC(P)
  • Immunogen
    Human acute myelogenous leukaemia cell line KG-1.
  • Format conjugation
    FITC
  • Specificity
    The MEM-186 antibody reacts with CD7, a 40 kD type I transmembrane glycoprotein expressed on peripheral blood T lymphocytes, NK-cells, hematopoietic progenitors, monocytes (weakly) and also on acute lymphocytic leukemia.HLDA VI; WS Code T 6T-015_x000D_
  • Research area
    CD and Related Antigens (Human)
  • Storage buffer
    The reagent is provided in stabilizing phosphate buffered saline (PBS) solution containing 15mM sodium azide.
  • Shipping and storage
    Mouse Monoclonal Antibody against Human CD7, Clone: MEM-186 is transported on blue ice/ice packs and should be stored at temperatures between 1 and 5 degrees Celsius. Do not freeze! Avoid exposing the product to direct light, especially the conjugated antibodies as most conjugates are very sentitive to light.
  • Background
    CD7, also known as gp40, is a member of the immunoglobulin superfamily found on T cells, NK cells, thymocytes, hematopoietic progenitors, and monocytes (weakly). CD7 is also expressed on acute lymphocytic leukemia (ALL). CD7 crosslinking induces a calcium flux in T lymphocytes, presumably as a result of cytoplasmic domain association with PI3-kinase. CD7 co-stimulation can induce cytokine secretion and modulate cellular adhesion. A ligand of CD7, epithelial cell secreted protein K12, is produced in thymus to regulate thymocyte signaling and cytokine release. In lung microvascular endothelial cells CD7 serves as an IgM Fc receptor. Expression of CD7 is an important marker used in leukemia diagnostics.
  • Purity
    > 95% (by SDS-PAGE)
  • Purification method
    Purified by affinity chromatography
  • Datasheet
    Datasheet
  • References
    *Leukocyte Typing VI., Kishimoto T. et al. (Eds.), Garland Publishing Inc. (1997).
  • Alternative to gene target
    • [ "CD7 molecule", "GP40 and LEU-9 and Tp40 and TP41", "CD7 and IDBG-73437 and ENSG00000173762 and 924", "protein binding", "Plasma membranes", "Cd7 and IDBG-214932 and ENSMUSG00000025163 and 12516", "CD7 and IDBG-642137 and ENSBTAG00000011359 and 510073" ]
  • Gene target
    CD7 monoclonal
    • Gene info
  • Gene symbol
    CD7
  • isotype filter
    • IgG1
  • technique filter
    • Antibody
  • Technique
    Antibody, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies
  • Alternative technique
    antibodies