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CD55 / DAF monoclonal antibody

  • Catalog number
    T8-230-T100
  • Product name
    CD55 / DAF monoclonal antibody
  • Size
    100 assays
  • Short name
    Anti-CD55 / DAF Mab
  • Long name
    Mouse Monoclonal Antibody against Human CD55 / DAF, Clone: MEM-118
  • Antigen
    CD55
  • Host
    Mouse (Mus musculus)
  • Species reactivity
    Human (Homo sapiens), Non-Human (Homo sapiens) Primates
  • Negative species reactivity
    at the time of upload there has been no data, please, contact us to obtain most recent information on species reactivity and cross reactivity
  • Clonality
    Monoclonal Antibody (Mab)
  • Clone
    MEM-118
  • Isotype
    IgM
  • Applications
    FC, IP, IHC(P)
  • Immunogen
    HPB-ALL human T cell line
  • Format conjugation
    PE-Cy 5
  • Specificity
    The antibody MEM-118 recognizes an epitope in SCR4 domain of CD55 (Decay accelerating factor, DAF), a 60-70 kDa glycosylphosphatidylinositol (GPI)-anchored single chain glycoprotein. CD55 is widely expressed on hematopoietic and on many non-hematopoietic cells; it is weakly present on NK cells.HLDA V; WS Code AS S016_x000D_
  • Research area
    CD Antigens & MHC (Veterinary), CD and Related Antigens (Human)
  • Storage buffer
    The reagent is provided in stabilizing Tris buffered saline (TBS) solution containing 15 mM sodium azide.
  • Shipping and storage
    Mouse Monoclonal Antibody against Human CD55 / DAF, Clone: MEM-118 is transported on blue ice/ice packs and should be stored at temperatures between 1 and 5 degrees Celsius. Do not freeze! Avoid exposing the product to direct light, especially the conjugated antibodies as most conjugates are very sentitive to light.
  • Background
    CD55 (decay-accelerating factor, DAF) is a GPI-anchored membrane glycoprotein that protects autologous cells from classical and alternative pathway of complement cascade. Bidirectional interactions between CD55 and CD97 are involved in T cell regulation and CD55 can still regulate complement when bound to CD97. In tumours, besides protection agains complement, CD55 promotes neoangiogenesis, tumorigenesis, invasiveness and evasion of apoptosis.
  • Purity
    > 95% (by SDS-PAGE)
  • Purification method
    Purified by affinity chromatography
  • Datasheet
    Datasheet
  • References
    *Angelisová P, Drbal K, Horejsí V, Cerný J: Association of CD10/neutral endopeptidase 24.11 with membrane microdomains rich in glycosylphosphatidylinositol-anchored proteins and Lyn kinase. Blood. 1999 Feb 15;93(4):1437-9., *Leukocyte Typing V., Schlossman S. et al. (Eds.), Oxford University Press (1995).
  • Alternative to gene target
    • [ "CD55 molecule, decay accelerating factor for complement (Cromer blood group)", "CR and CROM and DAF and TC", "CD55 and IDBG-106331 and ENSG00000196352 and 1604", "lipid binding", "Extracellular", "CD55 and IDBG-629269 and ENSBTAG00000006984 and 518609" ]
  • Gene target
    CD55 / DAF monoclonal
    • Gene info
    Locus Specific Databases:Blood Group Antigen Mutation DatabaseCD55base: Mutation registry for Decay-accelerating factor (CD55) deficiency (previously known as DAFbase)LRG_127
  • Gene symbol
    CD55
  • isotype filter
    • IgM
  • technique filter
    • Antibody
  • Technique
    Antibody, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies
  • Alternative technique
    antibodies