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CD42b / GPIb alpha monoclonal antibody

  • Catalog number
    1A-367-T100
  • Product name
    CD42b / GPIb alpha monoclonal antibody
  • Size
    100 assays
  • Short name
    Anti-CD42b / GPIb alpha Mab
  • Long name
    Mouse Monoclonal Antibody against Human CD42b / GPIb alpha, Clone: HIP1
  • Antigen
    CD42b
  • Host
    Mouse (Mus musculus)
  • Species reactivity
    Human (Homo sapiens), Non-Human (Homo sapiens) Primates
  • Negative species reactivity
    at the time of upload there has been no data, please, contact us to obtain most recent information on species reactivity and cross reactivity
  • Clonality
    Monoclonal Antibody (Mab)
  • Clone
    HIP1
  • Isotype
    IgG1
  • Applications
    FC, IHC(F), FUNC
  • Immunogen
    Peripheral blood mononuclear cells of a patient suffering with CLL.
  • Format conjugation
    APC
  • Specificity
    The antibody HIP1 reacts with CD42b (GPIb alpha), a 135-145 kDa membrane glycoprotein expressed on platelets and megakaryocytes. CD42b and CD42c (GPIb beta) are composed in a disulfide linked heterodimer (CD42b/c; 160 kDa); CD42b/c forms a noncovalent complex with CD42a and CD42d._x000D_ HLDA IV; WS Code P 40
  • Research area
    CD Antigens & MHC (Veterinary), CD and Related Antigens (Human)
  • Storage buffer
    The reagent is provided in stabilizing phosphate buffered saline (PBS) solution containing 15mM sodium azide.
  • Shipping and storage
    Mouse Monoclonal Antibody against Human CD42b / GPIb alpha, Clone: HIP1 is transported on blue ice/ice packs and should be stored at temperatures between 1 and 5 degrees Celsius. Do not freeze! Avoid exposing the product to direct light, especially the conjugated antibodies as most conjugates are very sentitive to light.
  • Background
    CD42b (GPIb alpha) composes together with GPIb beta, GPIX and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular wight kininogen, TSP-1, integrin Mac-1 and P-selectin. The extracellular domain of CD42b by its interactions also contributes to metastasis.
  • Purity
    > 95% (by SDS-PAGE)
  • Purification method
    Purified by affinity chromatography
  • Datasheet
    Datasheet
  • References
    *Takahashi R, Sekine N, Nakatake T: Influence of monoclonal antiplatelet glycoprotein antibodies on in vitro human megakaryocyte colony formation and proplatelet formation. Blood. 1999 Mar 15;93(6):1951-8._x000D_ _x000D_ _x000D_ , *Leukocyte Typing IV., Knapp W et al. (Eds.), Oxford University Press (1989).
  • Gene target
    CD42b / GPIb alpha monoclonal
  • isotype filter
    • IgG1
  • technique filter
    • Antibody
  • Technique
    Antibody, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies
  • Alternative technique
    antibodies