gentaur logogentaur logo
x

CD34 monoclonal antibody

  • Catalog number
    11-664-C100
  • Product name
    CD34 monoclonal antibody
  • Size
    100ug
  • Short name
    Anti-CD34 Mab
  • Long name
    Mouse Monoclonal Antibody against Human CD34, Clone: 581
  • Antigen
    CD34
  • Host
    Mouse (Mus musculus)
  • Species reactivity
    Human (Homo sapiens), Non-Human (Homo sapiens) Primates
  • Negative species reactivity
    at the time of upload there has been no data, please, contact us to obtain most recent information on species reactivity and cross reactivity
  • Clonality
    Monoclonal Antibody (Mab)
  • Clone
    581
  • Isotype
    IgG1
  • Applications
    FC, IHC(F)
  • Format conjugation
    purified; unconjugated
  • Specificity
    The mouse monoclonal antibody 581 reacts with CD34 (Mucosialin), a 110-115 kDa monomeric transmembrane phosphoglycoprotein expressed on hematopoietic progenitors cells and on the most pluripotential stem cells; it is gradually lost on progenitor cells. The antibody recognizes the class III CD34 epitope resistant to neuraminidase, chymopapain and glycoprotease._x000D_ HLDA V.; WS Code MA27
  • Research area
    CD and Related Antigens (Human)
  • Concentration
    1 mg/ml
  • Storage buffer
    Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
  • Shipping and storage
    Mouse Monoclonal Antibody against Human CD34, Clone: 581 is transported on blue ice/ice packs and should be stored at temperatures between 1 and 5 degrees Celsius. Do not freeze! Avoid exposing the product to direct light, especially the conjugated antibodies as most conjugates are very sentitive to light.
  • Background
    CD34 is a highly glycosylated monomeric 111-115 kDa surface protein, which is present on many stem cell populations. It is a well established stem cell marker, though its expression on human hematopoietic stem cells is reversible. CD34 probably serves as a surface receptor that undergoes receptor-mediated endocytosis and regulates adhesion, differentiation and proliferation of hematopoietic stem cells and other progenitors. CD34 expression is likely to represent a specific state of hematopoietic development that may have altered adhering properties with expanding and differentiating capabilities in both in vitro and in vivo conditions.
  • Purity
    > 95% (by SDS-PAGE)
  • Purification method
    Purified by protein-A affinity chromatography
  • Datasheet
    Datasheet
  • References
    , *Ando K, Nakamura Y, Chargui J, Matsuzawa H, Tsuji T, Kato S, Hotta T: Extensive generation of human cord blood CD34(+) stem cells from Lin(-)CD34(-) cells in a long-term in vitro system. Exp Hematol. 2000 Jun;28(6):690-9.
  • Alternative to gene target
    • [ "CD34 molecule", "CD34 and IDBG-106399 and ENSG00000174059 and 947", "sulfate binding", "Extracellular", "Cd34 and IDBG-209317 and ENSMUSG00000016494 and 12490", "CD34 and IDBG-638449 and ENSBTAG00000010562 and 281051" ]
  • Gene target
    CD34 monoclonal
    • Gene info
  • Gene symbol
    CD34
  • isotype filter
    • IgG1
  • technique filter
    • Antibody
  • Technique
    Antibody, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies
  • Alternative technique
    antibodies