- Catalog number11-750-C025
- Product nameCD160 monoclonal antibody
- Size25ug
- PriceAsk For Price
- Short nameAnti-CD160 Mab
- Long nameMouse Monoclonal Antibody against Human CD160, Clone: BY55
- AntigenCD160
- HostMouse (Mus musculus)
- Species reactivityHuman (Homo sapiens)
- Negative species reactivityat the time of upload there has been no data, please, contact us to obtain most recent information on species reactivity and cross reactivity
- ClonalityMonoclonal Antibody (Mab)
- CloneBY55
- IsotypeIgM
- ApplicationsFC, IP
- ImmunogenHuman NK cell line YT2C2
- Format conjugationpurified; unconjugated
- SpecificityThe mouse monoclonal antibody BY55 recognizes CD160, a 27 kDa glycoprotein expressed on NK cells, NK-T cells, intestinal intraepithelial lymphocytes, TCR-gamma/delta T cells and a small population of TCR-alpha/beta T cells. The antibody detects both GPI-anchored and transmembrane form of CD160.
- Research areaCD and Related Antigens (Human)
- Concentration1 mg/ml
- Storage bufferTris buffered saline (TBS) with 15 mM sodium azide, approx. pH 8.0
- Shipping and storageMouse Monoclonal Antibody against Human CD160, Clone: BY55 is transported on blue ice/ice packs and should be stored at temperatures between 1 and 5 degrees Celsius. Do not freeze! Avoid exposing the product to direct light, especially the conjugated antibodies as most conjugates are very sentitive to light.
- BackgroundCD160 is a cell surface glycoprotein of immunoglobulin superfamily, which functions as a costimulatory receptor expressed mainly on cytotoxic cell populations and recognizing both classical and non-classical MHC class I molecules. It can form disulfide-linked multimers. Down-modulation of CD160 occurs as a consequence of its proteolytic cleavage and the released soluble form was found to impair the MHC-class I specific cytotoxicity of CD8+ T lymphocytes and NK cells. In contrast to GPI-anchored isoform with broader expression among CD160 positive cells, expression of the transmembrane isoform is restricted to NK cells and is activation-dependent.
- Purity> 95% (by SDS-PAGE)
- Purification methodPurified by precipitation and chromatography
- Datasheet
- References*Merino J, Ramírez N, Moreno C, Toledo E, Fernández M, Sánchez-Ibarrola A: BY55/CD160 cannot be considered a cytotoxic marker in cytomegalovirus-specific human CD8(+) T cells. Clin Exp Immunol. 2007 Jul;149(1):87-96., *Anumanthan A, Bensussan A, Boumsell L, Christ AD, Blumberg RS, Voss SD, Patel AT, Robertson MJ, Nadler LM, Freeman GJ: Cloning of BY55, a novel Ig superfamily member expressed on NK cells, CTL, and intestinal intraepithelial lymphocytes. J Immunol. 1998 Sep 15;161(6):2780-90., *Maïza H, Leca G, Mansur IG, Schiavon V, Boumsell L, Bensussan A: A novel 80-kD cell surface structure identifies human circulating lymphocytes with natural killer activity. J Exp Med. 1993 Sep 1;178(3):1121-6., *Giustiniani J, Bensussan A, Marie-Cardine A: Identification and characterization of a transmembrane isoform of CD160 (CD160-TM), a unique activating receptor selectively expressed upon human NK cell activation. J Immunol. 2009 Jan 1;182(1):63-71., *Bensussan A, Gluckman E, el Marsafy S, Schiavon V, Mansur IG, Dausset J, Boumsell L, Carosella E: BY55 monoclonal antibody delineates within human cord blood and bone marrow lymphocytes distinct cell subsets mediating cytotoxic activity. Proc Natl Acad Sci U S A. 1994 Sep 13;91(19):9136-40.
- Alternative to gene target
- [ "CD160 molecule", "BY55 and NK1 and NK28", "CD160 and IDBG-101772 and ENSG00000117281 and 11126", "MHC class I receptor activity", "Plasma membranes", "Cd160 and IDBG-176450 and ENSMUSG00000038304 and 54215" ]
- Gene targetCD160 monoclonal
- Identity:HGNC:17013
- Gene:CD160
- Long gene name:CD160 molecule
- Synonyms gene name:CD160 antigen
- Synonyms:BY55NK1NK28
- Discovery year:2003-10-02
- Entrez gene record:11126
- Pubmed identification:9743336, 9973372
- RefSeq identity:NM_007053
- Classification:Immunoglobulin like domain containing, CD molecules
- VEGA ID:OTTHUMG00000013749
- Gene symbolCD160
- isotype filter
- IgM
- technique filter
- Antibody
- TechniqueAntibody, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies
- Alternative techniqueantibodies