- Catalog number1P-609-T025
- Product nameCD158d / KIR2DL4 monoclonal antibody
- Size25 assays
- PriceAsk For Price
- Short nameAnti-CD158d / KIR2DL4 Mab
- Long nameMouse Monoclonal Antibody against Human CD158d / KIR2DL4, Clone: mAb#33
- AntigenCD158d / KIR2DL4
- HostMouse (Mus musculus)
- Species reactivityHuman (Homo sapiens)
- Negative species reactivityat the time of upload there has been no data, please, contact us to obtain most recent information on species reactivity and cross reactivity
- ClonalityMonoclonal Antibody (Mab)
- ClonemAb#33
- IsotypeIgG1
- ApplicationsFC, IP, WB, ICC, FUNC
- ImmunogenNK3.3 cells and KIR2DL4-Ig fusion protein_x000D_
- Format conjugationPE
- SpecificityThe mouse monoclonal antibody mAb#33 (also known as mAb 33 or 33) recognizes extracellular portion of CD158d / KIR2DL4, a 45 kDa NK cell marker. Cell surface expression and function of CD158d / KIR2DL4 depends on genotype of particular individuals._x000D_
- Research areaCD and Related Antigens (Human)
- Storage bufferThe reagent is provided in stabilizing phosphate buffered saline (PBS) solution containing 15mM sodium azide.
- Shipping and storageMouse Monoclonal Antibody against Human CD158d / KIR2DL4, Clone: mAb#33 is transported on blue ice/ice packs and should be stored at temperatures between 1 and 5 degrees Celsius. Do not freeze! Avoid exposing the product to direct light, especially the conjugated antibodies as most conjugates are very sentitive to light.
- BackgroundCD158d / KIR2DL4 is a KIR family member that shares structural features with both activating and inhibitory receptors and may mediate different functions under different circumstances. It contains cytoplasmic ITIM, suggesting inhibitory function, but also transmembrane domain similar to those of activating KIRs. It has been reported that CD158d serves as an inhibitory receptor for peripheral and uterine NK cells, but its ligation with soluble mAbs (unlike immobilized mAbs) results in activation of IFN-γ secretion. CD158d also binds both membrane form and soluble form of its ligand HLA-G._x000D_
- Purity> 95% (by SDS-PAGE)
- Purification methodPurified by affinity chromatography
- Datasheet
- References*LeMaoult J, Zafaranloo K, Le Danff C, Carosella ED: HLA-G up-regulates ILT2, ILT3, ILT4, and KIR2DL4 in antigen presenting cells, NK cells, and T cells. FASEB J. 2005 Apr;19(6):662-4._x000D_ , *Yan WH, Fan LA: Residues Met76 and Gln79 in HLA-G alpha1 domain involve in KIR2DL4 recognition. Cell Res. 2005 Mar;15(3):176-82._x000D_ , *Rajagopalan S, Bryceson YT, Kuppusamy SP, Geraghty DE, van der Meer A, Joosten I, Long EO. Activation of NK cells by an endocytosed receptor for soluble HLA-G. PLoS Biol. 2006 Jan;4(1):e9._x000D_ , *Goodridge JP, Witt CS, Christiansen FT, Warren HS: KIR2DL4 (CD158d) genotype influences expression and function in NK cells. J Immunol. 2003 Aug 15;171(4):1768-74._x000D_ , *Rajagopalan S, Fu J, Long EO: Cutting edge: induction of IFN-gamma production but not cytotoxicity by the killer cell Ig-like receptor KIR2DL4 (CD158d) in resting NK cells. J Immunol. 2001 Aug 15;167(4):1877-81._x000D_
- Alternative to gene target
- [ "killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4", "CD158D and G9P and KIR-103AS and KIR103 and KIR103AS", "KIR2DL4 and IDBG-69383 and ENSG00000189013 and 3805", "protein binding", "Plasma membranes" ]
- Gene targetCD158d / KIR2DL4 monoclonal
- Identity:HGNC:6332
- Gene:KIR2DL4
- Long gene name:killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4
- Synonyms gene name:killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4
- Synonyms:103AS15.212CD158D
- Discovery year:1997-11-14
- Entrez gene record:3805
- Pubmed identification:8946682
- RefSeq identity:NM_002255
- Classification:CD molecules, Killer cell immunoglobulin like receptors
- VEGA ID:OTTHUMG00000065880
- Gene symbolKIR2DL4
- isotype filter
- IgG1
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- Antibody
- TechniqueAntibody, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies
- Alternative techniqueantibodies
Gene info
Locus Specific Databases:IPD-KIR Database