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beta2-Microglobulin monoclonal antibody

  • Catalog number
    1F-237-C025
  • Product name
    beta2-Microglobulin monoclonal antibody
  • Size
    25ug
  • Short name
    Anti-beta2-Microglobulin Mab
  • Long name
    Mouse Monoclonal Antibody against Human beta2-Microglobulin, Clone: B2M-01
  • Antigen
    beta2-Microglobulin
  • Host
    Mouse (Mus musculus)
  • Species reactivity
    Human (Homo sapiens)
  • Negative species reactivity
    Mouse, Rabbit, Canine (Dog), Chicken, Bovine
  • Clonality
    Monoclonal Antibody (Mab)
  • Clone
    B2M-01
  • Isotype
    IgG2a
  • Applications
    FC, IP, WB, IHC(P), ICC, ELISA, RIA
  • Immunogen
    Purified human beta2-microglobulin
  • Format conjugation
    FITC
  • Specificity
    The antibody B2M-01 reacts with beta2-microglobulin (beta2M) associated with cell-surface MHC Class I molecules and other membrane antigens as well as with soluble beta2-microglobulin. Beta2M is a 12 kDa Ig like glycoprotein expressed on lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells and epithelial cells. It is absent on erythrocytes._x000D_
  • Research area
    Serum & Plasma Proteins (Human), MHC (Major Histocompatibility Complex) and Related Antigens (Human)
  • Concentration
    1 mg/ml
  • Storage buffer
    Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
  • Shipping and storage
    Mouse Monoclonal Antibody against Human beta2-Microglobulin, Clone: B2M-01 is transported on blue ice/ice packs and should be stored at temperatures between 1 and 5 degrees Celsius. Do not freeze! Avoid exposing the product to direct light, especially the conjugated antibodies as most conjugates are very sentitive to light.
  • Background
    Beta2-microglobulin non-covalently associates with the 44 kDa alpha chain to forms the HLA Class I antigen complex. Human beta2-microglobulin associated with HLA Class I antigens is expressed on many types of cells including lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells, and epithelial cells. It is absent on erythrocytes.
  • Purity
    > 95% (by SDS-PAGE)
  • Purification method
    Purified by affinity chromatography
  • Datasheet
    Datasheet
  • References
    *Poláková K, Železníková T, Russ G: HLA-G5 in the blood of leukemia patients and healthy individuals. Leuk Res. 2013 Feb;37(2):139-45. , *Lafon M, Prehaud C, Megret F, Lafage M, Mouillot G, Roa M, Moreau P, Rouas-Freiss N, Carosella ED: Modulation of HLA-G Expression in Human Neural Cells after Neurotropic Viral Infections. J Virol. 2005 Dec; 79(24): 15226-15237., *Hilgert I, Horejsi V, Kristofova H: The use of murine monoclonal antibody B2M-01 for detection and purification of_x000D_ human beta 2-microglobulin. Folia Biol (Praha). 1984;30(6):369-76. _x000D_ , *Khurana M, Traum AZ, Aivado M, Wells MP, Guerrero M, Grall F, Libermann TA, Schachter AD: Urine proteomic profiling of pediatric nephrotic syndrome. Pediatr Nephrol. 2006 Sep;21(9):1257-65. Epub 2006 Jun 30. _x000D_
  • Gene target
    beta2-Microglobulin monoclonal
  • isotype filter
    • IgG2a
  • technique filter
    • Antibody
  • Technique
    Antibody, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies
  • Alternative technique
    antibodies