- Catalog numberPKSR030179-20µg
- Product nameRecombinant Rat Coagulation Factor III / Tissue Factor / CD142 Protein (His tag) 20µg
- Size20µg
- PriceAsk For Price
- SynonymF3
- ActivityNA
- SequenceMet1-Glu252
- Fusion tagC-His
- AccessionQ66HI4
- ExpressedHostHEK293 Cells
- ShippingIn general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
- Purity> 95 % as determined by SDS-PAGE
- Endotoxin< 1.0 EU per μg of the protein as determined by the LAL method
- Stability and StorageSamples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
- Mol Mass27.2 kDa
- AP Mol Mass47-52 KDa
- FormulationLyophilized from sterile PBS, pH 7.4
- BackgroundTissue factor (TF), also known as coagulation factor III, F3, and CD142, is a single-pass type I membrane protein which belongs to the tissue factor family. Tissue factor is one of the proteins that participate in hemostatic and inflammatory processes. Activated monocytes present in the liver increase expression of tissue factor, and while accumulating in the organ they can intensify inflammation. Tissue factor is the protein that activates the blood clotting system by binding to, and activating, the plasma serine protease, factor VIIa, following vascular injury. Tissue factor is not only the main physiological initiator of normal blood coagulation, but is also important in the natural history of solid malignancies in that it potentiates metastasis and angiogenesis and mediates outside-in signalling. Tissue factor is expressed constitutively by many tissues which are not in contact with blood and by other cells upon injury or activation; the latter include endothelial cells, tissue macrophages, and peripheral blood monocytes. Coagulation Factor III is a transmembrane glycoprotein that localizes the coagulation serine protease factor VII/VIIa (FVII/VIIa) to the cell surface. The primary function of TF is to activate the clotting cascade. The TF:FVIIa complex also activates cells by cleavage of a G-protein coupled receptor called protease-activated receptor 2 (PAR2). TF is expressed by tumor cells and contributes to a variety of pathologic processes, such as thrombosis, metastasis, tumor growth, and tumor angiogenesis. As a key regulator of haemostasis and angiogenesis, it is also involved in the pathology of several diseases, including cardiovascular, inflammatory and neoplastic conditions.
- Technical Data
- Gene targetCoagulation Factor III / Tissue Factor / CD142 Protein His tag 20µg
- Identity:HGNC:3541
- Gene:F3
- Long gene name:coagulation factor III, tissue factor
- Synonyms gene name:coagulation factor III (thromboplastin, tissue factor)
- Synonyms:CD142TF
- Discovery year:2001-06-22
- Entrez gene record:2152
- RefSeq identity:NM_001993
- Classification:CD molecules
- VEGA ID:OTTHUMG00000010716
- Identity:HGNC:27652
- Gene:CPLX3
- Long gene name:complexin 3
- Synonyms:CPX-III
- Discovery year:2005-08-02
- Entrez gene record:594855
- Pubmed identification:15911881
- RefSeq identity:NM_001030005
- VEGA ID:OTTHUMG00000142816
- Identity:HGNC:7046
- Gene:MGAT3
- Long gene name:beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
- Synonyms gene name:mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
- Synonyms:GNT-III
- Discovery year:1993-08-27
- Entrez gene record:4248
- Pubmed identification:8370666
- RefSeq identity:NM_002409
- Classification:Mannosyl-glycoprotein N-acetylglucosaminyltransferases
- VEGA ID:OTTHUMG00000030185
- Identity:HGNC:30135
- Gene:P4HA3
- Long gene name:prolyl 4-hydroxylase subunit alpha 3
- Synonyms gene name:procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide III, prolyl 4-hydroxylase, alpha polypeptide III
- Synonyms:C-P4Halpha(III),
- Discovery year:2004-05-12
- Entrez gene record:283208
- Pubmed identification:14500733
- RefSeq identity:NM_182904
- VEGA ID:OTTHUMG00000165254
- Identity:HGNC:1506
- Gene:CASP5
- Long gene name:caspase 5
- Synonyms gene name:caspase 5, apoptosis-related cysteine protease, caspase 5, apoptosis-related cysteine peptidase
- Synonyms:ICE(rel)III,
- Discovery year:1996-09-13
- Entrez gene record:838
- Pubmed identification:7797592, 9250871
- RefSeq identity:NM_004347
- Classification:Caspases, Caspase recruitment domain containing
- VEGA ID:OTTHUMG00000048073
- Identity:HGNC:23187
- Gene:THAP4
- Long gene name:THAP domain containing 4
- Synonyms:CGI-36Nb(III)
- Discovery year:2003-10-08
- Entrez gene record:51078
- Pubmed identification:12575992, 10810093, 30524950
- RefSeq identity:NM_015963
- Classification:THAP domain containing
- VEGA ID:OTTHUMG00000133410
- Identity:HGNC:5709
- Gene:IGHVIII-82
- Long gene name:immunoglobulin heavy variable (III)-82 (pseudogene)
- Synonyms gene name:immunoglobulin heavy variable (III)-82, immunoglobulin heavy variable (III)-82 pseudogene
- Synonyms:IGHV(III)-82,
- Discovery year:2000-04-17
- Entrez gene record:28338
- RefSeq identity:NG_001019
- Classification:Immunoglobulin heavy locus at 14q32.33
- VEGA ID:OTTHUMG00000151732
- Identity:HGNC:7426
- Gene:MT-CSB3
- Long gene name:mitochondrially encoded conserved sequence block III
- Synonyms gene name:conserved sequence block III
- Synonyms:CSB-III
- Discovery year:1989-10-11
- Pubmed identification:2982153
- Classification:Mitochondrially encoded regions
- Identity:HGNC:5707
- Gene:IGHVIII-67-4
- Long gene name:immunoglobulin heavy variable (III)-67-4 (pseudogene)
- Synonyms gene name:immunoglobulin heavy variable (III)-67-4, immunoglobulin heavy variable (III)-67-4 pseudogene
- Synonyms:IGHV(III)-67-4,
- Discovery year:2000-04-17
- Entrez gene record:28340
- RefSeq identity:NG_001019
- Classification:Immunoglobulin heavy locus at 14q32.33
- VEGA ID:OTTHUMG00000151874
- Gene symbolF3, CPLX3, MGAT3, MGST3, P4HA3, CASP5, THAP4, IGHVIII-82, MT-CSB3, IGHVIII-67-4
- HostRat
- Short nameRecombinant Coagulation Factor III / Tissue Factor / CD142 Protein (His tag) 20µg
- LabelHis
- label filter
- His
- technique filter
- Recombinant
- tissue
- TechniqueRecombinant, tissue, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags, tissues
- Alternative techniquerec, tissues
- Tissuetissue
- tissue filter
- tissue
Gene info
Locus Specific Databases:LRG_552