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Recombinant Mouse Kallikrein 7 Protein

  • Catalog number
    PKSM040437-10µg
  • Product name
    Recombinant Mouse Kallikrein 7 Protein
  • Size
    10µg
  • Synonym
    Kallikrein-7; Klk7; Serine protease 6; Stratum corneum chymotryptic enzyme; Thymopsin; kallikrein-related peptidase 7; PRSS6; SCCEkallikrein-7
  • Activity
    Measured by its ability to cleave the fluorogenic peptide substrate, Mca-RPKPVE-Nval-WRK(Dnp)-NH2 (AnaSpec, Cat#27114).The specific activity is >70 pmoles/min/μg.(Activation description: The proenzyme needs to be activated by Thermolysin for an activated form)
  • Sequence
    Met1-Arg249
  • Fusion tag
    C-6His
  • Accession
    Q91VE3
  • Expressed Host
    Human Cells
  • Shipping
    In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
  • Purity
    ＞95% as determined by reducing SDS-PAGE.
  • Stability and Storage
    Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months
  • Mol Mass
    26.1 kDa
  • AP Mol Mass
    28-35 kDa
  • Formulation
    Lyophilized from a 0.2 μm filtered solution of 20mM HEPES,150mM NaCl,pH7.4.
  • Background
    Kallikrein7, also named as stratum corneum chymotryptic enzyme (SCCE), is a secreted protein of the Kallikrein-related peptidase (KLK) family. This family contains fifteen homologous secreted serine endopeptidases and plays a significant role in various physiological processes, including skin desquamation, semen liquefaction, neural plasticity, and body fluid homeostasis. In skin KLK5, KLK 7 and KLK14 are able to degrade corneodesmosomes, which leads to desquamation of skin surface cells. KLK activation is believed to be mediated through highly organized proteolytic cascades, regulated through a series of feedback loops, inhibitors, auto-degradation and internal cleavages. Studies have shown that one potential physiological activator for KLK7 is KLK5. Along with KLK14, these three kallikreins form a proteolytic cascade in the stratum corneum. KLK7 is primarily expressed in the skin but is also detected at relatively high levels in esophagus, heart, liver, central nervous system, kidney, pancreas, mammary and salivary glands.
  • Technical data
    Technical_data
  • Gene target
    Kallikrein 7 Protein
  • Host
    mouse
  • Short name
    Recombinant Mouse Kallikrein 7 Protein
  • technique filter
    • Recombinant
    • Mouse
  • Technique
    Recombinant, Mouse, mouses, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
  • Alternative technique
    rec, murine