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Recombinant Mouse FGFR1 / CD331 Protein (His tag)

  • Catalog number
    PKSM040821-50µg
  • Product name
    Recombinant Mouse FGFR1 / CD331 Protein (His tag)
  • Size
    50µg
  • Synonym
    AW208770;bFGF-R-1;c-fgr;Eask;Fgfr-1;FLG;Flt-2;Hspy;MFR
  • Activity
    NA
  • Sequence
    Met 1-Glu 376
  • Fusion tag
    C-His
  • Accession
    P16092-1
  • Expressed Host
    HEK293 Cells
  • Shipping
    In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
  • Purity
    > 97 % as determined by SDS-PAGE
  • Endotoxin
    < 1.0 EU per μg of the protein as determined by the LAL method
  • Stability and Storage
    Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Mol Mass
    40.9 kDa
  • AP Mol Mass
    55-65 kDa
  • Formulation
    Lyophilized from sterile PBS, pH 7.4
  • Background
    FGFR1, also known as CD331, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. Fibroblast growth factors (FGFs) (FGF1 - 10 and 16 - 23) are mitogenic signaling molecules that have roles in angiogenesis, wound healing, cell migration, neural outgrowth and embryonic development. FGFs bind heparan sulfate glycosaminoglycans, which facilitates dimerization (activation) of FGF receptors. FGFR1 is a full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of FGFR1 interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. CD331 can be detected in astrocytoma, neuroblastoma and adrenal cortex cell lines. Some isoforms are detected in foreskin fibroblast cell lines, however isoform 17, isoform 18 and isoform 19 are not detected in these cells. Defects in FGFR1 are a cause of Pfeiffer syndrome ，idiopathic hypogonadotropic hypogonadism， Kallmann syndrome type 2, osteoglophonic dysplasia and trigonocephaly non-syndromic.Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy
  • Technical data
    Technical_data
  • Alternative to gene target
    • [ "fibroblast growth factor receptor 1", "bFGF-R-1 and BFGFR and CD331 and CEK and FGFBR and FGFR-1 and FLG and FLT-2 and FLT2 and HBGFR and HH2 and HRTFDS and KAL2 and N-SAM and OGD", "FGFR1 and IDBG-17796 and ENSG00000077782 and 2260", "transferase activity", "nuclei", "Fgfr1 and IDBG-143767 and ENSMUSG00000031565 and 14182", "FGFR1 and IDBG-629273 and ENSBTAG00000015457 and 281768" ]
  • Gene target
    FGFR1 / CD331 Protein His tag
    • Gene info
    Locus Specific Databases:LRG_993
  • Gene symbol
    FGFR1
  • Host
    mouse
  • Short name
    Recombinant Mouse FGFR1 / CD331 Protein (His tag)
  • Label
    His
  • label filter
    • His
  • technique filter
    • Recombinant
    • Mouse
  • Technique
    Recombinant, Mouse, mouses, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
  • Alternative technique
    rec, murine