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Recombinant Mouse Cytotoxic T-lymphocyte Protein 4Protein(C-Flag)

  • Catalog number
    PKSM041000-10µg
  • Product name
    Recombinant Mouse Cytotoxic T-lymphocyte Protein 4Protein(C-Flag)
  • Size
    10µg
  • Synonym
    Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4, CTLA-4, CD152, Ctla4
  • Activity
    NA
  • Sequence
    Ala37-Asp161
  • Fusion tag
    C-Flag
  • Accession
    P09793
  • Expressed Host
    Human Cells
  • Shipping
    The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
  • Purity
    ＞95% as determined by reducing SDS-PAGE.
  • Stability and Storage
    Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months
  • Mol Mass
    14.7 kDa
  • AP Mol Mass
    20-25 kDa
  • Formulation
    Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
  • Background
    Mouse Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule. Within the ECD, Mouse CTLA-4 shares 68% aa sequence identity with human. CTLA4 is similar to the T cell costimulatory protein CD28 since both of the molecules bind to CD80 and CD86 on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found inregulatory T cells and may play an important role in their functions. T cell activation through the T cell receptor and CD28 leads to increased expression of CTLA4. Genetic variations of CTLA4 have been associated with susceptibility to systemic lupus erythematosus(SLE), Gravesdisease(GRD), Celiac disease type3(CELIAC3) and Hepatitis B virus infection(HBVinfection).
  • Technical data
    Technical_data
  • Gene target
    Cytotoxic T-lymphocyte Protein 4Protein C
  • Host
    mouse
  • Short name
    Recombinant Mouse Cytotoxic T-lymphocyte Protein 4Protein(C- )
  • Label
    Flag
  • label filter
    • Flag
  • technique filter
    • Recombinant
    • Mouse
  • Technique
    Recombinant, Mouse, mouses, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
  • Alternative technique
    rec, murine
  • Tissue
    lymphocyte
  • tissue filter
    • lymphocyte