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Recombinant Mouse Cathepsin A / CTSA Protein (His tag) 50µg

  • Catalog number
    PKSM040722-50µg
  • Product name
    Recombinant Mouse Cathepsin A / CTSA Protein (His tag) 50µg
  • Size
    50µg
  • Activity
    NA
  • Synonym
    AU019505;PPCA;Ppgb
  • Sequence
    Met 1-Tyr 474
  • Fusion tag
    C-His
  • Accession
    P16675-1
  • Expressed Host
    HEK293 Cells
  • Shipping
    In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
  • Purity
    > 96 % as determined by SDS-PAGE
  • Endotoxin
    < 1.0 EU per μg of the protein as determined by the LAL method
  • Stability and Storage
    Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Mol Mass
    52.8 kDa
  • AP Mol Mass
    52.8 kDa
  • Formulation
    Lyophilized from sterile 25mM Tris, 0.3M NaCl, pH 8.0
  • Background
    Lysosomal carboxypeptidase, cathepsin A (protective protein, CathA), is a component of the lysosomal multienzyme complex along with beta-galactosidase (GAL) and sialidase Neu1, where it activates Neu1 and protects GAL and Neu1 against the rapid proteolytic degradation. Cathepsin A is a multicatalytic enzyme with deamidase and esterase in addition to carboxypeptidase activities. It was recently identified in human platelets as deamidase. In vitro, it hydrolyzes a variety of bioactive peptide hormones including tachykinins, suggesting that extralysosomal cathepsin A plays a role in regulation of bioactive peptide functions. It is a member of the alpha/beta hydrolase fold family and has been suggested to share a common ancestral relationship with other alpha/beta hydrolase fold enzymes, such as cholinesterases. Cathepsin A defects are linked to multiple forms of Galactosialidosis with a combined secondary deficiency of beta-galactosidase and neuraminidase. Cathepsin A is a key molecule in the onset of galactosialidosis and also highlight the therapeutic acts in vivo as an endothelin-1-inactivating enzyme and strongly confirm a crucial role of this enzyme in effective elastic fiber formation.
  • Technical data
    Technical_data
  • Alternative to gene target
    • [ "cathepsin A", "GLB2 and GSL and NGBE and PPCA and PPGB", "CTSA and IDBG-78417 and ENSG00000064601 and 5476", "enzyme activator activity", "nuclei", "Ctsa and IDBG-212379 and ENSMUSG00000017760 and 19025", "CTSA and IDBG-642969 and ENSBTAG00000027337 and 518169" ]
  • Gene target
    Cathepsin A / CTSA Protein His tag 50µg
    • Gene info
  • Gene symbol
    CTSA
  • Host
    mouse
  • Short name
    Recombinant Mouse Cathepsin A / CTSA Protein (His tag) 50µg
  • Label
    His
  • label filter
    • His
  • technique filter
    • Recombinant
    • Mouse
  • Technique
    Recombinant, Mouse, mouses, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
  • Alternative technique
    rec, murine