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Recombinant Human Follistatin / FST (FS288) Protein (His tag)

  • Catalog number
    PKSH030733-20µg
  • Product name
    Recombinant Human Follistatin / FST (FS288) Protein (His tag)
  • Size
    20µg
  • Synonym
    FS
  • Activity
    Measured by its ability to neutralize Activin-mediated inhibition on MPC11 cell proliferation.The ED50 for this effect is typically 0.2-1 μg/mL in the presence of 10 ng/ml Recombinant Human Activin A.
  • Sequence
    Met 1-Asn 317
  • Fusion tag
    C-His
  • Accession
    P19883-2
  • Expressed Host
    HEK293 Cells
  • Shipping
    In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
  • Purity
    ＞90 % as determined by SDS-PAGE
  • Endotoxin
    ＜1.0 EU per µg as determined by the LAL method
  • Stability and Storage
    Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Mol Mass
    33 kDa
  • AP Mol Mass
    45 kDa
  • Formulation
    Lyophilized from sterile PBS, pH 7.4
  • Background
    Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. follistatin are expressed and subserve local regulatory roles in numerous extragonadal tissues, including brain, adrenal, bone marrow, and placenta but perhaps most notably in anterior pituitary-the classical target tissue for inhibin, the activin-follistatin system may play a key role in early embryogenesis. Follistatin binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone follistatin is a binding protein to activin. Since activin binds to follistatin, it is imperative to determine the nature of the activin/follistatin binding complex.
  • Technical data
    Technical_data
  • Gene target
    Follistatin / FST FS288 Protein His tag
    • Gene info
  • Gene symbol
    FST
  • Short name
    Recombinant Follistatin / FST (FS288) Protein (His tag)
  • Label
    His
  • label filter
    • His
  • technique filter
    • Recombinant
  • Technique
    Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
  • Alternative technique
    rec