- Catalog numberPKSH030526-100µg
- Product nameRecombinant Human BBOX1 / Gamma-BBH Protein (His & GST tag) 100µg
- Size100µg
- PriceAsk For Price
- SynonymBBH;BBOX;G-BBH;gamma-BBH
- ActivityNA
- SequenceMet1-Asn387
- Fusion tagN-His & GST
- AccessionO75936
- Expressed HostBaculovirus-Insect Cells
- ShippingIn general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
- Purity＞85 % as determined by SDS-PAGE
- Endotoxin＜1.0 EU per µg as determined by the LAL method
- Stability and StorageSamples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
- Mol Mass72.5 kDa
- AP Mol Mass65 kDa
- FormulationLyophilized from sterile 20mM Tris, 500mM NaCl, 10% glycerol, pH 8.0
- ReconstitutionPlease refer to it for detailed information.
- BackgroundBBOX1, also known as gamma-BBH, belongs to the gamma-BBH/TMLD family. It is highly expressed in kidney and moderately expressed in liver. BBOX1 catalyzes the formation of L-carnitine from gamma-butyrobetaine, the last step in the L-carnitine biosynthetic pathway. Carnitine is essential for the transport of activated fatty acids across the mitochondrial membrane during mitochondrial beta-oxidation. BBOX1 is an inhibition target for mildronate which can be used to treat angina andmyocardial infarction. Mildronate may also be beneficial for the treatment ofneurological disorder, diabetes, and seizures and alcohol intoxication.
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- Gene targetBBOX1 / Gamma-BBH Protein His GST tag 100µg
- Identity:HGNC:964
- Gene:BBOX1
- Long gene name:gamma-butyrobetaine hydroxylase 1
- Synonyms gene name:butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
- Synonyms:gamma-BBHG-BBHBBH
- Discovery year:1999-02-26
- Entrez gene record:8424
- Pubmed identification:9753662
- RefSeq identity:NM_003986
- VEGA ID:OTTHUMG00000166121
- Identity:HGNC:50700
- Gene:BBOX1-AS1
- Long gene name:BBOX1 antisense RNA 1
- Discovery year:2014-06-09
- Entrez gene record:103695435
- Pubmed identification:31984680
- Classification:Antisense RNAs
- VEGA ID:OTTHUMG00000166122
- Gene symbolBBOX1, MGST3, BBOX1-AS1
- Short nameRecombinant BBOX1 / Gamma-BBH Protein (His & GST tag) 100µg
- LabelHis
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- His
- technique filter
- Recombinant
- TechniqueRecombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
- Alternative techniquerec