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Rabbit Anti Human TNFRSF21 Antibody-Non-conjugated

  • Catalog number
    CSB-PA023979DSR2HU_100ul
  • Product name
    Rabbit Anti Human TNFRSF21 Antibody-Non-conjugated
  • Size
    100ul
  • Long name
    Rabbit Antibody against Human TNFRSF21, Non-conjugated
  • Short name
    Anti-TNFRSF21
  • Synonym name
    TNFRSF21 Human Antibody
  • Host
    Rabbit, Rabbits
  • Species reactivity
    Human
  • Tested applications recommended dilutions
    ELISA,WB,IHC;Recommended dilution:WB:1:200-1000,IHC:1:20-1:200
  • Conjugation
    Non-conjugated
  • Antibody isotype
    IgG
  • UniProt ID
    O75509
  • Format
    Liquid, diluted in buffer
  • Buffer composition
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • Purity
    >95%
  • Purification method
    Antigen Affinity Purified Antibodies
  • Antibody category
    Polyclonal Antibodies
  • Immunogen type
    Recombinant human Tumor necrosis factor receptor superfamily member 21 protein (371-655AA)
  • Immunogen species
    Human
  • Alias
    Death receptor 6,CD358,TNFRSF21,DR6,UNQ437/PRO868
  • Background
    Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21; this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negatively regulates the production of IgG, IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T-cell stimulation.
  • Clonality
    Polyclonal antibody
  • Shipping and storage
    TNFRSF21 Antibody is shipped on ice packs and upon receipt should be stored at -20 or -80 degrees Celsius. We recommend that you prepare the working aliquots in advance so that freez-thaw cycles are avoided. Do not expose the antibodies to drirect bright light, especially the labeled ones as most conjugates are light sensitive.
  • Alternative to gene target
    • [ "tumor necrosis factor receptor superfamily, member 21", "TNFRSF21 and IDBG-90063 and ENSG00000146072 and 27242", "protein binding", "Plasma membranes", "Tnfrsf21 and IDBG-184035 and ENSMUSG00000023915 and 94185", "TNFRSF21 and IDBG-632394 and ENSBTAG00000020054 and 537922" ]
  • Gene target
    TNFRSF21 Non-conjugated
    • Gene info
  • Gene symbol
    TNFRSF21
  • technique filter
    • anti human
    • Antibody
    • Rabbit
    • anti
  • Technique
    anti human, Antibody, Rabbit, anti, antibody to, anti human antibodies, antibodies against human proteins, antibodies for, antibody Conjugates
  • Alternative technique
    antibodies, rabbit-anti