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Rabbit Anti Human TIMELESS Antibody-Non-conjugated

  • Catalog number
    CSB-PA892360LA01HU_100ug
  • Product name
    Rabbit Anti Human TIMELESS Antibody-Non-conjugated
  • Size
    100ug
  • Long name
    Rabbit Antibody against Human TIMELESS, Non-conjugated
  • Short name
    Anti-TIMELESS
  • Synonym name
    TIMELESS Human Antibody
  • Host
    Rabbit, Rabbits
  • Species reactivity
    Human
  • Tested applications recommended dilutions
    ELISA, IHC; Recommended dilution: IHC:1:200-1:500
  • Conjugation
    Non-conjugated
  • Antibody isotype
    IgG
  • UniProt ID
    Q9UNS1
  • Format
    Liquid, diluted in buffer
  • Buffer composition
    Preservative: 0.03% Proclin 300, Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • Purity
    >95%
  • Purification method
    Protein G purified
  • Antibody category
    Polyclonal Antibodies
  • Immunogen type
    Recombinant Human Protein timeless homolog protein (1004-1131AA)
  • Immunogen species
    Human
  • Alias
    Protein timeless homolog, hTIM, TIMELESS
  • Background
    Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication and in the regulation of the circadian clock. Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock. Negatively regulates CLOCK|NPAS2-ARTNL/BMAL1|ARTNL2/BMAL2-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus. Forms a complex with TIPIN and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress. Timeless promotes TIPIN nuclear localization. Involved in cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. May also play an important role in epithelial cell morphogenesis and formation of branching tubules.
  • Clonality
    Polyclonal antibody
  • Shipping and storage
    TIMELESS Antibody is shipped on ice packs and upon receipt should be stored at -20 or -80 degrees Celsius. We recommend that you prepare the working aliquots in advance so that freez-thaw cycles are avoided. Do not expose the antibodies to drirect bright light, especially the labeled ones as most conjugates are light sensitive.
  • Short name of the antigen
    Protein timeless homolog
  • Gene target
    TIMELESS Non-conjugated
    • Gene info
  • Gene symbol
    TIMELESS
  • technique filter
    • anti human
    • Antibody
    • Rabbit
    • anti
  • Technique
    anti human, Antibody, Rabbit, anti, antibody to, anti human antibodies, antibodies against human proteins, antibodies for, antibody Conjugates
  • Alternative technique
    antibodies, rabbit-anti