- Catalog numberCSB-PA861164LB01HU_50ug
- Product nameRabbit Anti Human SLC26A6 Antibody-HRP
- Size50ug
- PriceAsk For Price
- Long nameRabbit Antibody against Human SLC26A6, HRP
- Short nameAnti-SLC26A6
- Synonym nameSLC26A6 Human Antibody
- HostRabbit, Rabbits
- Species reactivityHuman
- Tested applications recommended dilutionsELISA
- ConjugationHRP
- Antibody isotypeIgG
- UniProt IDQ9BXS9
- FormatLiquid, diluted in buffer
- Buffer compositionPreservative: 0.03% Proclin 300, Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
- Purity>95%
- Purification methodProtein G purified
- Antibody categoryPolyclonal Antibodies
- Immunogen typeRecombinant Human Solute carrier family 26 member 6 protein (554-668AA)
- Immunogen speciesHuman
- AliasSolute carrier family 26 member 6, Anion exchange transporter, Pendrin-like protein 1, Pendrin-L1, SLC26A6
- BackgroundApical membrane anion-exchanger with wide epithelial distribution that plays a role as a component of the pH buffering system for maintaining acid-base homeostasis. Acts as a versatile DIDS-sensitive inorganic and organic anion transporter that mediates the uptake of monovalent anions like chloride, bicarbonate, formate and hydroxyl ion and divalent anions like sulfate and oxalate. Function in multiple exchange modes involving pairs of these anions, which include chloride-bicarbonate, chloride-oxalate, oxalate-formate, oxalate-sulfate and chloride-formate exchange. Apical membrane chloride-bicarbonate exchanger that mediates luminal chloride absorption and bicarbonate secretion by the small intestinal brush border membrane and contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption, possibly by providing a bicarbonate import pathway. Mediates also intestinal chloride absorption and oxalate secretion, thereby preventing hyperoxaluria and calcium oxalate urolithiasis. Transepithelial oxalate secretion, chloride-formate, chloride-oxalate and chloride-bicarbonate transport activities in the duodenum are inhibited by PKC activation in a calcium-independent manner. The apical membrane chloride-bicarbonate exchanger provides also a major route for fluid and bicarbonate secretion into the proximal tubules of the kidney as well as into the proximal part of the interlobular pancreatic ductal tree, where it mediates electrogenic chloride-bicarbonate exchange with a chloride-bicarbonate stoichiometry of 1:2, and hence will dilute and alkalinize protein-rich acinar secretion. Mediates also the transcellular sulfate absorption and oxalate secretion across the apical membrane in the duodenum and the formate ion efflux at the apical brush border of cells in the proximal tubules of kidney. Plays a role in sperm capacitation by increasing intracellular pH.
- ClonalityPolyclonal antibody
- Shipping and storageSLC26A6 Antibody is shipped on ice packs and upon receipt should be stored at -20 or -80 degrees Celsius. We recommend that you prepare the working aliquots in advance so that freez-thaw cycles are avoided. Do not expose the antibodies to drirect bright light, especially the labeled ones as most conjugates are light sensitive.
- Short name of the antigenSolute carrier family 26 member 6
- Gene targetSLC26A6 -
- Identity:HGNC:14472
- Gene:SLC26A6
- Long gene name:solute carrier family 26 member 6
- Synonyms gene name:solute carrier family 26, member 6, solute carrier family 26 (anion exchanger), member 6
- Synonyms:DKFZp586E1422,
- Discovery year:2001-01-25
- Entrez gene record:65010
- Pubmed identification:11087667, 11247665
- RefSeq identity:NM_022911
- Classification:Solute carriers, MicroRNA protein coding host genes
- VEGA ID:OTTHUMG00000186381
- Gene symbolSLC26A6
- LabelHRP
- label filter
- HRP
- technique filter
- anti human
- Antibody
- Rabbit
- anti
- Techniqueanti human, Antibody, Rabbit, anti, antibody to, anti human antibodies, antibodies against human proteins, antibodies for
- Alternative techniqueantibodies, rabbit-anti