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Rabbit Anti Human SLC26A6 Antibody-HRP

  • Catalog number
    CSB-PA861164LB01HU_50ug
  • Product name
    Rabbit Anti Human SLC26A6 Antibody-HRP
  • Size
    50ug
  • Long name
    Rabbit Antibody against Human SLC26A6, HRP
  • Short name
    Anti-SLC26A6
  • Synonym name
    SLC26A6 Human Antibody
  • Host
    Rabbit, Rabbits
  • Species reactivity
    Human
  • Tested applications recommended dilutions
    ELISA
  • Conjugation
    HRP
  • Antibody isotype
    IgG
  • UniProt ID
    Q9BXS9
  • Format
    Liquid, diluted in buffer
  • Buffer composition
    Preservative: 0.03% Proclin 300, Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • Purity
    >95%
  • Purification method
    Protein G purified
  • Antibody category
    Polyclonal Antibodies
  • Immunogen type
    Recombinant Human Solute carrier family 26 member 6 protein (554-668AA)
  • Immunogen species
    Human
  • Alias
    Solute carrier family 26 member 6, Anion exchange transporter, Pendrin-like protein 1, Pendrin-L1, SLC26A6
  • Background
    Apical membrane anion-exchanger with wide epithelial distribution that plays a role as a component of the pH buffering system for maintaining acid-base homeostasis. Acts as a versatile DIDS-sensitive inorganic and organic anion transporter that mediates the uptake of monovalent anions like chloride, bicarbonate, formate and hydroxyl ion and divalent anions like sulfate and oxalate. Function in multiple exchange modes involving pairs of these anions, which include chloride-bicarbonate, chloride-oxalate, oxalate-formate, oxalate-sulfate and chloride-formate exchange. Apical membrane chloride-bicarbonate exchanger that mediates luminal chloride absorption and bicarbonate secretion by the small intestinal brush border membrane and contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption, possibly by providing a bicarbonate import pathway. Mediates also intestinal chloride absorption and oxalate secretion, thereby preventing hyperoxaluria and calcium oxalate urolithiasis. Transepithelial oxalate secretion, chloride-formate, chloride-oxalate and chloride-bicarbonate transport activities in the duodenum are inhibited by PKC activation in a calcium-independent manner. The apical membrane chloride-bicarbonate exchanger provides also a major route for fluid and bicarbonate secretion into the proximal tubules of the kidney as well as into the proximal part of the interlobular pancreatic ductal tree, where it mediates electrogenic chloride-bicarbonate exchange with a chloride-bicarbonate stoichiometry of 1:2, and hence will dilute and alkalinize protein-rich acinar secretion. Mediates also the transcellular sulfate absorption and oxalate secretion across the apical membrane in the duodenum and the formate ion efflux at the apical brush border of cells in the proximal tubules of kidney. Plays a role in sperm capacitation by increasing intracellular pH.
  • Clonality
    Polyclonal antibody
  • Shipping and storage
    SLC26A6 Antibody is shipped on ice packs and upon receipt should be stored at -20 or -80 degrees Celsius. We recommend that you prepare the working aliquots in advance so that freez-thaw cycles are avoided. Do not expose the antibodies to drirect bright light, especially the labeled ones as most conjugates are light sensitive.
  • Short name of the antigen
    Solute carrier family 26 member 6
  • Gene target
    SLC26A6 -
    • Gene info
  • Gene symbol
    SLC26A6
  • Label
    HRP
  • label filter
    • HRP
  • technique filter
    • anti human
    • Antibody
    • Rabbit
    • anti
  • Technique
    anti human, Antibody, Rabbit, anti, antibody to, anti human antibodies, antibodies against human proteins, antibodies for
  • Alternative technique
    antibodies, rabbit-anti