- Catalog numberCSB-PA624010HA01HU_100ug
- Product nameRabbit Anti Human SART3 Antibody-Non-conjugated
- Size100ug
- PriceAsk For Price
- Long nameRabbit Antibody against Human SART3, Non-conjugated
- Short nameAnti-SART3
- Synonym nameSART3 Human Antibody
- HostRabbit, Rabbits
- Species reactivityHuman
- Tested applications recommended dilutionsELISA,IHC;Recommended dilution:IHC:1:20-1:200
- ConjugationNon-conjugated
- Antibody isotypeIgG
- UniProt IDQ15020
- FormatLiquid, diluted in buffer
- Buffer compositionPreservative: 0.03% Proclin 300, Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
- Purity>95%
- Purification methodProtein G purified
- Antibody categoryPolyclonal Antibodies
- Immunogen typeRecombinant human Squamous cell carcinoma antigen recognized by T-cells 3 protein (600-900AA)
- Immunogen speciesHuman
- AliasSquamous cell carcinoma antigen recognized by T-cells 3Curated,SART-3Imported,SART3,Tat-interacting protein of 110 kDa1
- BackgroundU6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassembly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation (PubMed:12032085). Also binds U6atac snRNPs and may function as a recycling factor for U4atac/U6atac spliceosomal snRNP, an initial step in the assembly of U12-type spliceosomal complex. The U12-type spliceosomal complex plays a role in the splicing of introns with non-canonical splice sites (PubMed:14749385). May also function as a substrate-targeting factor for deubiquitinases like USP4 and USP15. Recruits USP4 to ubiquitinated PRPF3 within the U4/U5/U6 tri-snRNP complex, promoting PRPF3 deubiquitination and thereby regulating the spliceosome U4/U5/U6 tri-snRNP spliceosomal complex disassembly (PubMed:20595234). May also recruit the deubiquitinase USP15 to histone H2B and mediate histone deubiquitination, thereby regulating gene expression and/or DNA repair (PubMed:24526689). May play a role in hematopoiesis probably through transcription regulation of specific genes including MYC (By similarity).
- ClonalityPolyclonal antibody
- Shipping and storageSART3 Antibody is shipped on ice packs and upon receipt should be stored at -20 or -80 degrees Celsius. We recommend that you prepare the working aliquots in advance so that freez-thaw cycles are avoided. Do not expose the antibodies to drirect bright light, especially the labeled ones as most conjugates are light sensitive.
- Alternative to gene target
- [ "squamous cell carcinoma antigen recognized by T cells 3", "DSAP1 and P100 and p110 and p110(nrb) and RP11-13G14 and TIP110", "SART3 and IDBG-55333 and ENSG00000075856 and 9733", "poly(A) RNA binding", "nuclei", "Sart3 and IDBG-191800 and ENSMUSG00000018974 and 53890", "BT.22766 and IDBG-635596 and ENSBTAG00000031846 and 505922" ]
- Gene targetSART3 Non-conjugated
- Identity:HGNC:16860
- Gene:SART3
- Long gene name:spliceosome associated factor 3, U4/U6 recycling protein
- Synonyms gene name:squamous cell carcinoma antigen recognized by T-cells 3, squamous cell carcinoma antigen recognized by T cells 3
- Synonyms:KIAA0156, RP11-13G14TIP110p110
- Discovery year:2001-12-17
- Entrez gene record:9733
- Pubmed identification:12032085, 15840095, 20595234
- Classification:RNA binding motif containing
- VEGA ID:OTTHUMG00000169449
- Gene symbolSART3
- technique filter
- anti human
- Antibody
- Rabbit
- anti
- Techniqueanti human, Antibody, Rabbit, anti, antibody to, anti human antibodies, antibodies against human proteins, antibodies for, antibody Conjugates
- Alternative techniqueantibodies, rabbit-anti
Gene info
Locus Specific Databases:LRG_1285