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Rabbit Anti Human RELA Antibody-FITC

  • Catalog number
    CSB-PA03987C0Rb_100ug
  • Product name
    Rabbit Anti Human RELA Antibody-FITC
  • Size
    100ug
  • Long name
    Rabbit Antibody against Human RELA, FITC
  • Short name
    Anti-RELA
  • Synonym name
    RELA Human Antibody
  • Host
    Rabbit, Rabbits
  • Species reactivity
    Human
  • Tested applications recommended dilutions
    ELISA
  • Conjugation
    FITC
  • Antibody isotype
    IgG
  • UniProt ID
    Q04206
  • Format
    Liquid, diluted in buffer
  • Buffer composition
    Preservative: 0.03% Proclin 300, Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • Purity
    >95%
  • Purification method
    Protein G purified
  • Antibody category
    Polyclonal Antibodies
  • Immunogen type
    Recombinant human Transcription factor p65 protein (1-210AA)
  • Immunogen species
    Human
  • Alias
    Nuclear factor NF-kappa-B p65 subunit,Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, RELA,NFKB3
  • Background
    NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators. The NF-kappa-B p65-p65 complex appears to be involved in invasin-mediated activation of IL-8 expression. The inhibitory effect of I-kappa-B upon NF-kappa-B the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1.
  • Clonality
    Polyclonal antibody
  • Shipping and storage
    RELA Antibody is shipped on ice packs and upon receipt should be stored at -20 or -80 degrees Celsius. We recommend that you prepare the working aliquots in advance so that freez-thaw cycles are avoided. Do not expose the antibodies to drirect bright light, especially the labeled ones as most conjugates are light sensitive.
  • Alternative to gene target
    • [ "v-rel reticuloendotheliosis viral oncogene homolog A (avian)", "NFKB3 and p65", "RELA and IDBG-57543 and ENSG00000173039 and 5970", "ankyrin repeat binding", "nuclei", "Rela and IDBG-132298 and ENSMUSG00000024927 and 19697", "BT.26220 and IDBG-644222 and ENSBTAG00000013895 and 508233" ]
  • Gene target
    RELA -
    • Gene info
    • Identity:HGNC:54185
    • Gene:RELA-DT
    • Long gene name:RELA divergent transcript
    • Discovery year:2019-02-21
    • Entrez gene record:105369347
    • Classification:Divergent transcripts
    Gene info
  • Gene symbol
    RELA-DT, RELA
  • Label
    FITC
  • label filter
    • FITC
  • technique filter
    • anti human
    • Antibody
    • Rabbit
    • anti
    • FITC
  • Technique
    anti human, Antibody, Rabbit, anti, FITC, antibody to, anti human antibodies, antibodies against human proteins, antibodies for, Fluorescein
  • Alternative technique
    antibodies, rabbit-anti, fluorescine