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Rabbit Anti Human PSEN1 Antibody-Non-conjugated

  • Catalog number
    CSB-PA018846ESR2HU_100ul
  • Product name
    Rabbit Anti Human PSEN1 Antibody-Non-conjugated
  • Size
    100ul
  • Long name
    Rabbit Antibody against Human PSEN1, Non-conjugated
  • Short name
    Anti-PSEN1
  • Synonym name
    PSEN1 Human Antibody
  • Host
    Rabbit, Rabbits
  • Species reactivity
    Human
  • Tested applications recommended dilutions
    ELISA,WB,IHC;Recommended dilution:WB:1:500-2000,IHC:1:20-1:200
  • Conjugation
    Non-conjugated
  • Antibody isotype
    IgG
  • UniProt ID
    P49768
  • Format
    Liquid, diluted in buffer
  • Buffer composition
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • Purity
    >95%
  • Purification method
    Antigen Affinity Purified Antibodies
  • Antibody category
    Polyclonal Antibodies
  • Immunogen type
    Recombinant human Presenilin-1 protein (1-160AA)
  • Immunogen species
    Human
  • Alias
    PS-1,Protein S182,PS1-CTF12,PSEN1,AD3, PS1, PSNL1
  • Background
    Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis.
  • Clonality
    Polyclonal antibody
  • Shipping and storage
    PSEN1 Antibody is shipped on ice packs and upon receipt should be stored at -20 or -80 degrees Celsius. We recommend that you prepare the working aliquots in advance so that freez-thaw cycles are avoided. Do not expose the antibodies to drirect bright light, especially the labeled ones as most conjugates are light sensitive.
  • Alternative to gene target
    • [ "presenilin 1", "AD3 and FAD and PS-1 and PS1 and S182", "PSEN1 and IDBG-11235 and ENSG00000080815 and 5663", "cadherin binding", "nuclei", "Psen1 and IDBG-155522 and ENSMUSG00000019969 and 19164", "PSEN1 and IDBG-646832 and ENSBTAG00000011757 and 282705" ]
  • Gene target
    PSEN1 Non-conjugated
    • Gene info
    Locus Specific Databases:Alzheimer Disease & Frontotemporal Dementia Mutation DatabaseALSOD, the Amyotrophic Lateral Sclerosis Online Genetic DatabaseLRG_224
  • Gene symbol
    PSEN1
  • technique filter
    • anti human
    • Antibody
    • Rabbit
    • anti
  • Technique
    anti human, Antibody, Rabbit, anti, antibody to, anti human antibodies, antibodies against human proteins, antibodies for, antibody Conjugates
  • Alternative technique
    antibodies, rabbit-anti