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Rabbit Anti Human PIN1 Antibody-Non-conjugated

  • Catalog number
    CSB-PA04619A0Rb_100ug
  • Product name
    Rabbit Anti Human PIN1 Antibody-Non-conjugated
  • Size
    100ug
  • Long name
    Rabbit Antibody against Human PIN1, Non-conjugated
  • Short name
    Anti-PIN1
  • Synonym name
    PIN1 Human Antibody
  • Host
    Rabbit, Rabbits
  • Species reactivity
    Human
  • Tested applications recommended dilutions
    ELISA,IHC;Recommended dilution:IHC:1:20-1:200
  • Conjugation
    Non-conjugated
  • Antibody isotype
    IgG
  • UniProt ID
    Q13526
  • Format
    Liquid, diluted in buffer
  • Buffer composition
    Preservative: 0.03% Proclin 300, Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • Purity
    >95%
  • Purification method
    Protein G purified
  • Antibody category
    Polyclonal Antibodies
  • Immunogen type
    Recombinant human Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 protein (1-163AA)
  • Immunogen species
    Human
  • Alias
    Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC:5.2.1.8),PIN1,Peptidyl-prolyl cis-trans isomerase Pin1,PPIase Pin1,Rotamase Pin1
  • Background
    Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs in a subset of proteins, resulting in conformational changes in the proteins (PubMed:21497122, PubMed:22033920). Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK (PubMed:16644721). Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation (PubMed:15664191). Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner (PubMed:17828269). Acts as a regulator of JNK cascade by binding to phosphorylated FBXW7, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation: degradation of FBXW7 leads to subsequent stabilization of JUN (PubMed:22608923).
  • Clonality
    Polyclonal antibody
  • Shipping and storage
    PIN1 Antibody is shipped on ice packs and upon receipt should be stored at -20 or -80 degrees Celsius. We recommend that you prepare the working aliquots in advance so that freez-thaw cycles are avoided. Do not expose the antibodies to drirect bright light, especially the labeled ones as most conjugates are light sensitive.
  • Alternative to gene target
    • [ "peptidylprolyl cis/trans isomerase, NIMA-interacting 1", "DOD and UBL5", "PIN1 and IDBG-26087 and ENSG00000127445 and 5300", "phosphothreonine binding", "nuclei", "PIN1 and IDBG-643081 and ENSBTAG00000016988 and 535470" ]
  • Gene target
    PIN1 Non-conjugated
    • Gene info
    • Identity:HGNC:55303
    • Gene:PIN1-DT
    • Long gene name:PIN1 divergent transcript
    • Discovery year:2020-10-15
    • Entrez gene record:100996288
    • Classification:Divergent transcripts
    Gene info
    Locus Specific Databases:LRG_847
  • Gene symbol
    PIN1-DT, PIN1
  • technique filter
    • anti human
    • Antibody
    • Rabbit
    • anti
  • Technique
    anti human, Antibody, Rabbit, anti, antibody to, anti human antibodies, antibodies against human proteins, antibodies for, antibody Conjugates
  • Alternative technique
    antibodies, rabbit-anti