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Rabbit Anti Human DDIT3 Antibody-Biotin

  • Catalog number
    CSB-PA006589LD01HU_100ug
  • Product name
    Rabbit Anti Human DDIT3 Antibody-Biotin
  • Size
    100ug
  • Long name
    Rabbit Antibody against Human DDIT3, Biotin
  • Short name
    Anti-DDIT3
  • Synonym name
    DDIT3 Human Antibody
  • Host
    Rabbit, Rabbits
  • Species reactivity
    Human
  • Tested applications recommended dilutions
    ELISA
  • Conjugation
    Biotin
  • Antibody isotype
    IgG
  • UniProt ID
    P35638
  • Format
    Liquid, diluted in buffer
  • Buffer composition
    Preservative: 0.03% Proclin 300, Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • Purity
    >95%
  • Purification method
    Protein G purified
  • Antibody category
    Polyclonal Antibodies
  • Immunogen type
    Recombinant human DNA damage-inducible transcript 3 protein (1-169AA)
  • Immunogen species
    Human
  • Alias
    DNA damage-inducible transcript 3 protein,DDIT-3,C/EBP zeta,C/EBP-homologous protein,CHOP,C/EBP-homologous protein 10,CHOP-10,CCAAT/enhancer-binding protein homologous protein,Growth arrest and DNA damage-inducible protein GADD153,DDIT3,CHOP,CHOP10,GADD153
  • Background
    Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response.
  • Clonality
    Polyclonal antibody
  • Shipping and storage
    DDIT3 Antibody is shipped on ice packs and upon receipt should be stored at -20 or -80 degrees Celsius. We recommend that you prepare the working aliquots in advance so that freez-thaw cycles are avoided. Do not expose the antibodies to drirect bright light, especially the labeled ones as most conjugates are light sensitive.
  • Alternative to gene target
    • [ "DNA-damage-inducible transcript 3", "CEBPZ and CHOP and CHOP-10 and CHOP10 and GADD153", "DDIT3 and IDBG-42805 and ENSG00000175197 and 1649", "sequence-specific DNA binding", "nuclei", "Ddit3 and IDBG-194880 and ENSMUSG00000025408 and 13198", "DDIT3 and IDBG-635159 and ENSBTAG00000031544 and 777788" ]
  • Gene target
    DDIT3 -
    • Gene info
  • Gene symbol
    DDIT3
  • Label
    Biotin
  • label filter
    • Biotin
  • technique filter
    • anti human
    • Antibody
    • Rabbit
    • anti
  • Technique
    anti human, Antibody, Rabbit, anti, antibody to, anti human antibodies, antibodies against human proteins, antibodies for
  • Alternative technique
    antibodies, rabbit-anti