- Catalog numberMBS438349
- Product nameCD74
- Size5x0.1 mg (With BSA & Azide at 0.2mg/mL)
- PriceAsk For Price
- Products typeAntibody
- Products short name[CD74]
- Products name syn[CLIP; DHLAG; Gamma chain of class II antigens; HLA class II histocompatibility antigen gamma chain; HLA-DR antigens-associated invariant chain; HLADR-gamma (HLADG); Ia antigen-associated invariant chain; la-gamma; Major histocompatibility complex class II invariant chain; MHC HLA-DR gamma chain]
- Other names[HLA class II histocompatibility antigen gamma chain; p33; HLA-DR-gamma; MHC HLA-DR gamma chain; Ia-associated invariant chain; gamma chain of class II antigens; HLA-DR antigens-associated invariant chain; CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated); CD74 molecule, major histocompatibility complex, class II invariant chain]
- Products gene name[CD74]
- Other gene names[CD74; II; DHLAG; HLADG; Ia-GAMMA]
- ClonalityMonoclonal
- IsotypeIgG1, kappa
- Clone[BU45]
- HostMouse
- ReactivityHuman.
- SpecificityRecognizes proteins of 33, 35 and 41kDa, which are identified as various isoforms of CD74. Its epitope is localized in the extracellular domain of CD74. CD74 is a type II transmembrane protein which binds to the peptide binding groove of newly synthesized MHC class II alpha/beta heterodimers and prevents their premature association with endogenous polypeptides. The CD74 molecule plays a critical role in the presentation of peptides, by the MHC class II antigens, to CD4 positive lymphocytes. CD74 is expressed on MHC class II positive cells including B cells, a subset of activated T cells, monocytes, dendritic cells and by various types of carcinomas. CD74 is expressed primarily by antigen presenting cells, such as B-lymphocytes (from before the pre-B cell stage to before the plasma cell stage), macrophages, and monocytes, and many epithelial cells. Anti-CD74 stains predominantly germinal center lymphocytes and B-cell lymphomas, but rarely T-cell lymphomas. Anti-CD74 has been shown to be useful in differentiating atypical fibroxanthoma (-) from malignant fibrous histiocytoma (+).
- Form200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
- Storage stabilityStore at 2 to 8 degree C. Antibody is stable for 24 months.
- Tested applicationELISA (EIA), Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB), Immunoprecipitation (IP), Immunohistology (IH)
- Alternative to gene target
- [ "CD74 molecule, major histocompatibility complex, class II invariant chain", "DHLAG and HLADG and Ia-GAMMA and II", "CD74 and IDBG-53594 and ENSG00000019582 and 972", "MHC class II protein binding", "Cell surfaces", "Cd74 and IDBG-150302 and ENSMUSG00000024610 and 16149", "BT.46809 and IDBG-646288 and ENSBTAG00000015228 and 613384" ]
- Gene targetCD74
- Identity:HGNC:1697
- Gene:CD74
- Long gene name:CD74 molecule
- Synonyms gene name:CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated), CD74 molecule, major histocompatibility complex, class II invariant chain
- Synonyms:CLIP,
- Discovery year:1986-01-01
- Entrez gene record:972
- Pubmed identification:6324166, 3001652
- RefSeq identity:NM_004355
- Classification:CD molecules
- VEGA ID:OTTHUMG00000163559
- Gene symbolCD74
- isotype filter
- IgG1
- kappa
- Short nameCD74