- Catalog numberPA1783
- Product nameliver Arginase Antibody
- Size0,1 mg
- PriceAsk For Price
- Target antigenliver Arginase
- ClonalityPolyclonal antibody
- ClonePolyclonal antibody
- Raised inrabbit
- Type of the antibodyIgG polyclonal antibody
- Product formfreeze-dried
- Reacts with specieshuman
- AnalysesWB
- ImmunogenA synthetic peptide corresponding to a sequence at the C-terminus of rat liver Arginase(307-323aa KREGNHKPETDYLKPPK), different from the related mouse sequence by two amino acids.
- Product configurationEach vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
- PurificationImmunogen affinity purified.
- SolubilizationThe powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
- Storage condtionsKeep the liver Arginase Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
- TipsThe liver Arginase Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
- BackgroundARG1(arginase, live) is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. The isoform encoded by ARG1, referred to as the liver, or A-I, isoform, contributes 98% of the arginase activity in liver but is also present in red cells. Using a rat liver ARG1 cDNA clone to probe a human liver cDNA library, Haraguchi et al.(1987) isolated and characterized a cDNA corresponding to the ARG1 gene. The ARG1 gene is mapped on 6q23.2 and the arginase gene contains 8 exons. By immunologic studies, 90% of the arginase in red blood cell and liver was precipitated by the antibody, whereas only 50% of the arginase in kidney, brain, and the gastrointestinal tract reacted with it. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene.
- Related articles1. Cardoso, M. L., Martins, E., Vasconcelos, R., Vilarinho, L., Rocha, J. Identification of a novel R21X mutation in the liver-type arginase gene (ARG1) in four Portuguese patients with argininemia. Hum. Mutat. 14: 355-356, 1999. 2. Grody, W. W., Dodson, A., Klein, D., Kern, R. M., Bassand, P., Cederbaum, S. D. Molecular genetic study of human arginase deficiency. (Abstract) Am. J. Hum. Genet. 45 (suppl.): A191 only, 1989. 3. Haraguchi, Y., Takiguchi, M., Amaya, Y., Kawamoto, S., Matsuda, I., Mori, M. Molecular cloning and nucleotide sequence of cDNA for human liver arginase. Proc. Nat. Acad. Sci. 84: 412-415, 1987.
- Gene NameARG1
- Protein NameArginase-1
- Gene Full Namearginase, liver
- SynonymsA I antibody|Al antibody|ARG 1 antibody|ARG1 antibody|ARGI1_HUMAN antibody|Arginase 1 antibody|Arginase liver antibody|Arginase type I antibody|Arginase-1 antibody|Arginase1 antibody|Liver type arginase antibody|Liver-type arginase antibody|Type I arginase antibody
- Uniprot IDP07824
- Gene targetliver Arginase
- Identity:HGNC:663
- Gene:ARG1
- Long gene name:arginase 1
- Synonyms gene name:arginase, liver
- Discovery year:2001-06-22
- Entrez gene record:383
- Pubmed identification:22959135
- VEGA ID:OTTHUMG00000015566
- Gene symbolARG1
- Short nameliver Arginase Antibody
- technique filter
- Antibody
- TechniqueAntibody, antibodies against human proteins, antibodies for
- Alternative techniqueantibodies
- Tissueliver
- tissue filter
- liver
Gene info
Locus Specific Databases:Global Variome shared LOVD