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Cpn10 Antibody

  • Catalog number
    PA1790
  • Product name
    Cpn10 Antibody
  • Size
    0,1 mg
  • Price
    Ask For Price
  • Contact us
    Cpn10 Antibody
  • Target antigen
    Cpn10
  • Clonality
    Polyclonal antibody
  • Clone
    Polyclonal antibody
  • Raised in
    rabbit
  • Type of the antibody
    IgG polyclonal antibody
  • Product form
    freeze-dried
  • Reacts with species
    human
  • Analyses
    WB,IHC-P,ICC
  • Immunogen
    A synthetic peptide corresponding to a sequence at the C-terminus of human Cpn10(81-102aa VVLDDKDYFLFRDGDILGKYVD), different from the related rat and mouse sequences by one amino acid.
  • Product configuration
    Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
  • Purification
    Immunogen affinity purified.
  • Solubilization
    The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
  • Storage condtions
    Keep the Cpn10 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
  • Tips
    The Cpn10 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
  • Background
    HSPE1(heat shock 10kDa protein 1(chaperonin 10)), also called CPN10, GROES, CHAPERONIN 10 HOMOLOG, cpn10 HOMOLOG or HSP10, is a protein that in humans is encoded by the HSPE1 gene. GroES is a heptameric ring of identical 10.4-kD subunits that binds to each end of GroEL to form a symmetric, functional heterodimer. The HSP10 gene consists of 4 exons. The HSPE1 gene is mapped to 2q33.1. The transcriptional activity of the promoter fragment in the HSP60 direction is approximately twice that in the HSP10 direction under normal growth conditions; upon heat shock, promoter activity in either direction increased by a factor of approximately 12. Mutational drifts performed in vitro with 4 different enzymes indicated the GroES overexpression doubled the number of accumulating mutations, and promoted the folding of enzyme variants carrying mutations in the protein core and/or mutations with higher destabilizing effects.
  • Related articles
    1. Georgopoulos, C., Welch, W. J. Role of the major heat shock proteins as molecular chaperones. Annu. Rev. Cell Biol. 9: 601-634, 1993. 2. Hansen, J. J., Bross, P., Westergaard, M., Nielsen, M. N., Eiberg, H., Borglum, A. D., Mogensen, J., Kristiansen, K., Bolund, L., Gregersen, N. Genomic structure of the human mitochondrial chaperonin genes: HSP60 and HSP10 are localised head to head on chromosome 2 separated by a bidirectional promoter. Hum. Genet. 112: 71-77, 2003. Note: Erratum: Hum. Genet. 112: 436 only, 2003. 3. Todd, M. J., Viitanen, P. V., Lorimer, G. H. Dynamics of the chaperonin ATPase cycle: implications for facilitated protein folding. Science 265: 659-666, 1994.
  • Gene Name
    HSPE1
  • Protein Name
    10 kDa heat shock protein, mitochondrial(Hsp10)
  • Gene Full Name
    heat shock 10kDa protein 1(chaperonin 10)
  • Synonyms
    10 kDa chaperonin antibody|10 kDa heat shock protein mitochondrial antibody|10 kDa heat shock protein, mitochondrial antibody|CH10_HUMAN antibody|Chaperonin 10 antibody|Cpn 10 antibody|CPN10 antibody|Early pregnancy factor antibody|Early-pregnancy factor antibody|EPF antibody|GROES antibody|Heat shock 10kD protein 1 antibody|Heat shock 10kD protein 1 chaperonin 10 antibody|Heat shock 10kDa protein 1 antibody|Heat shock 10kDa protein 1 chaperonin 10 antibody|HSP 10 antibody|HSP10 antibody|HSPE 1 antibody|HSPE1 antibody
  • Uniprot ID
    P61604
  • Gene target
    Cpn10
    • Gene info
  • Gene symbol
    HSPE1
  • Short name
    Cpn10 Antibody
  • technique filter
    • Antibody
  • Technique
    Antibody, antibodies against human proteins, antibodies for
  • Alternative technique
    antibodies