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Human CellExp™ Progranulin (untagged), Mouse Recombinant

  • Catalog number
    4733-50
  • Product name
    Human CellExp™ Progranulin (untagged), Mouse Recombinant
  • Size
    50 ug
  • Synonyms
    Recombinant Mouse Progranulin (Untagged)
  • Alternative names
    Proepithelin, PEPI, PC Cell-derived Growth Factor.
  • Description
    Regulator of cell growth, wound healing, and tumorigenesis
  • Recombinant
    Yes
  • Source
    HEK 293 cells
  • Purity by SDS PAGE
    ≥95%
  • Assay
    SDS-PAGE
  • Molecular Weight
    ~65.0 kDa
  • Storage Temp
    -20°C
  • Shipping
    Gel pack
  • Shelf Life
    12 months
  • Appearance
    Lyophilized protein
  • Physical form description
    Lyophilized from 0.2 um-filtered solution in PBS, pH 7.2.
  • Reconstitution Instructions
    Reconstitute in distilled water
  • Background Information
    Progranulin (PGRN), also called proepithelin and PC cell-derived growth factor, is a single precursor protein of granulins which are a family of secreted, glycosylated peptides. It is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of fronto-temporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer‘s Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.
  • Amino acid sequence
    Signal peptide and mouse progranulin (aa 1-589) is untagged. Reflects the native sequence with no additional amino acids.
  • Handling
    Centrifuge the vial prior to opening.
  • Usage
    For Research Use Only! Not to be used in humans
  • Datasheet
    Datasheet
  • Gene target
    CellExp™ Progranulin untagged
  • Host
    mouse
  • Short name
    CellExp™ Progranulin (untagged), Mouse Recombinant
  • technique filter
    • Recombinant
    • Mouse
  • Technique
    Recombinant, Mouse, mouses, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
  • Alternative technique
    rec, murine