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Anti-TNSF13B (Belimumab), Human IgG1 Antibody

  • Catalog number
    A2170-100
  • Product name
    Anti-TNSF13B (Belimumab), Human IgG1 Antibody
  • Size
    100 µg
  • Antibody Target
    TNFSF13B
  • Target Alternative Name
    LymphoStat B, LymphoStat-B, DTL, BAFF, BLYS, CD257, TALL1, THANK, ZTNF4, TALL-1, TNLG7A, TNFSF20
  • Antibody Type
    Monoclonal
  • Isotype
    IgG1, lambda, IgG1
  • Species Reactivities
    Human
  • Immunogen Sequence
    Human TNFSF13B
  • Accession
    DB08879
  • Appearance
    Colorless liquid
  • Form
    Liquid
  • Concentration
    1 mg/ml
  • Formulation
    In PBS, pH 7.5
  • Purification
    Protein A purified
  • Application
    In vitro studies
  • Application And Usages
    In vitro studies
  • Description
    The research-grade biosimilar is a recombinant fully human IgG1 monoclonal antibody that specifically binds to soluble human B lymphocyte stimulator protein (BLyS), also known as B-cell activating factor (BAFF). BAFF belongs to the superfamily of Tumor Necrosis Factor (TNF) and plays a vital role in B-cell maturation and survival. It is produced by several cell types such as neutrophils, dendritic cells, and macrophages. Binding of BLyS to its receptors on the surface of B-cells activates downstream signaling pathways such as NF-κB and MAPK pathways that promote the expression of anti-apoptotic proteins and inhibit apoptosis. The antibody binds to BLyS, prevents the association with its receptors, and thereby reduces the survival of autoantibody-producing B-cells. The original drug received approval from the FDA to treat systemic lupus erythematosus.
  • Storage Condition
    -80ºC
  • Shipping Condition
    Gel Pack
  • Shelf Life
    12 months
  • Usage
    For Research Use Only! Not to be used in humans.
  • Handling
    The antibody solution should be gently mixed before use.
  • Western Blot Verified
    0
  • Immunocytochemistry Verified
    0
  • Immunofluorescence Verified
    0
  • Immunoprecipitation Verified
    0
  • FACS Verified
    0
  • ELISA Verified
    0
  • ChIP Verified
    0
  • Dot Blot Verified
    0
  • Flow Cytometry Verified
    0
  • Data Sheet Link
    Data_Sheet_Link
  • Gene target
    TNSF13B Belimumab IgG1
  • isotype filter
    • IgG1
    • lambda
  • Short name
    Anti-TNSF13B (Belimumab), IgG1 Antibody
  • technique filter
    • Antibody
    • anti-
    • anti
  • Technique
    Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
  • Alternative technique
    antibodies