- Catalog numberA2249-100
- Product nameAnti-PD-1 (Cemiplimab), Human IgG4 Antibody
- Size100 µg
- PriceAsk For Price
- Antibody TargetPD-1
- Target Alternative NamePD1, PD-1, CD279, SLEB2, hPD-1, hPD-l, hSLE1, PDCD1, HPD-L
- Antibody TypeMonoclonal
- IsotypeIgG4, kappa
- Species ReactivitiesHuman
- Immunogen SequenceHuman PD-1
- AccessionDB14707
- Gene Id5133
- AppearanceColorless liquid
- FormLiquid
- FormulationIn PBS, pH 7.5
- PurificationProtein A purified
- DescriptionThe research-grade biosimilar is a human recombinant IgG4 monoclonal antibody that targets programmed cell death-1 (PD-1) protein. PD-1 is an important immune checkpoint protein expressed on activated T-cells, B-cells, and macrophages. Binding of PD-1 to its ligands PD-L1 and PD-L2 prevent T-cell activation and cytokine production. The monoclonal antibody binds to PD-1 on T-cells and prevents its interaction with the ligands, thereby reactivating T-cells and inhibiting tumor growth. The original monoclonal antibody is approved by the FDA to treat patients with metastatic cutaneous squamous cell carcinoma (CSCC) and those patients with locally advanced CSCC but are not candidates for curative surgery or curative radiation
- Storage Condition-80ºC
- Shipping ConditionGel Pack
- Shelf Life12 months
- UsageFor Research Use Only! Not to be used in humans.
- HandlingThe antibody solution should be gently mixed before use.
- Western Blot Verified0
- Immunocytochemistry Verified0
- Immunofluorescence Verified0
- Immunoprecipitation Verified0
- FACS Verified0
- ELISA Verified0
- ChIP Verified0
- Dot Blot Verified0
- Flow Cytometry Verified0
- Data Sheet Link
- Gene targetPD-1 Cemiplimab IgG4
- Identity:HGNC:8760
- Gene:PDCD1
- Long gene name:programmed cell death 1
- Synonyms gene name:systemic lupus erythematosus susceptibility 2
- Synonyms:CD279PD1hSLE1PD-1
- Discovery year:1994-05-24
- Entrez gene record:5133
- Pubmed identification:7851902, 12402038
- RefSeq identity:NM_005018
- Classification:V-set domain containing, CD molecules
- VEGA ID:OTTHUMG00000151342
- Identity:HGNC:14681
- Gene:SPATA2
- Long gene name:spermatogenesis associated 2
- Synonyms:KIAA0757PD1tamoPPP1R145
- Discovery year:2001-03-15
- Entrez gene record:9825
- RefSeq identity:NM_006038
- Classification:Protein phosphatase 1 regulatory subunits
- VEGA ID:OTTHUMG00000032704
- Identity:HGNC:11138
- Gene:SNCA
- Long gene name:synuclein alpha
- Synonyms gene name:Parkinson disease (autosomal dominant, Lewy body) 4, synuclein, alpha (non A4 component of amyloid precursor)
- Synonyms:NACP, PD1
- Discovery year:1995-01-24
- Entrez gene record:6622
- Pubmed identification:8248242, 14593171
- VEGA ID:OTTHUMG00000130948
- Identity:HGNC:3358
- Gene:ENPP3
- Long gene name:ectonucleotide pyrophosphatase/phosphodiesterase 3
- Synonyms:PD-IBETAgp130RB13-6B10CD203c
- Discovery year:1995-08-10
- Entrez gene record:5169
- Pubmed identification:9344668
- Classification:Ectonucleotide pyrophosphatase/phosphodiesterase family, CD molecules
- VEGA ID:OTTHUMG00000016292
- Identity:HGNC:18731
- Gene:PDCD1LG2
- Long gene name:programmed cell death 1 ligand 2
- Synonyms:PD-L2BtdcPDL2bA574F11.2CD273B7-DC
- Discovery year:2003-11-14
- Entrez gene record:80380
- Pubmed identification:11224527
- RefSeq identity:NM_025239
- Classification:B7 family, CD molecules, Immunoglobulin like domain containing, Receptor ligands
- VEGA ID:OTTHUMG00000019504
- Identity:HGNC:17635
- Gene:CD274
- Long gene name:CD274 molecule
- Synonyms gene name:programmed cell death 1 ligand 1, CD274 antigen
- Synonyms:B7-H, B7H1PD-L1PDL1B7-H1
- Discovery year:2003-11-13
- Entrez gene record:29126
- Pubmed identification:11015443, 10581077
- RefSeq identity:NM_014143
- Classification:Receptor ligands, C2-set domain containing, V-set domain containing, B7 family, CD molecules
- VEGA ID:OTTHUMG00000019503
- Identity:HGNC:5670
- Gene:IGHVII-1-1
- Long gene name:immunoglobulin heavy variable (II)-1-1 (pseudogene)
- Synonyms gene name:immunoglobulin heavy variable (II)-1-1, immunoglobulin heavy variable (II)-1-1 pseudogene
- Synonyms:IGHV(II)-1-1,
- Discovery year:2000-04-17
- Entrez gene record:28377
- RefSeq identity:NG_001019
- Classification:Immunoglobulin heavy locus at 14q32.33
- VEGA ID:OTTHUMG00000152325
- Identity:HGNC:31499
- Gene:MIR1-1
- Long gene name:microRNA 1-1
- Synonyms:hsa-mir-1-1
- Discovery year:2004-04-23
- Entrez gene record:406904
- RefSeq identity:NR_029780
- Classification:MicroRNA MIR1/206 family
- Identity:HGNC:50820
- Gene:TRUND-NNN8-1
- Long gene name:tRNA-undetermined (NNN) 8-1
- Synonyms gene name:transfer RNA-undetermined (NNN) 8-1
- Discovery year:2014-06-20
- Entrez gene record:103482528
- Pubmed identification:18984615
- Gene symbolPDCD1, ENPP2, SPATA2, SNCA, ENPP3, PDCD1LG2, CD274, IGHVII-1-1, MIR1-1, TRUND-NNN8-1
- isotype filter
- IgG4
- kappa
- Short nameAnti-PD-1 (Cemiplimab), IgG4 Antibody
- technique filter
- Antibody
- anti-
- anti
- TechniqueAntibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
- Alternative techniqueantibodies
Gene info
Gene info
Gene info
Gene info
Locus Specific Databases:Global Variome shared LOVD