- Catalog numberA2011-200
- Product nameAnti-CD80 (Galiximab), Human IgG1, lambda Antibody
- Size200 µg
- PriceAsk For Price
- Antibody TargetCD80
- Target Alternative NameB7-1; T-lymphocyte activation antigen CD80; Activation B7-1 antigen; BB1; CTLA-4 counter-receptor B7.1; B7
- Antibody TypeMonoclonal
- CloneIDEC-114 (Galiximab)
- IsotypeHuman IgG1, lambda, IgG1
- Species ReactivitiesHuman
- Immunogen SequenceGaliximab was prepared by immunizing cynomolgus monkeys with recombinant CD80 antigen. The variable regions of the light and heavy chains were then cloned by being incorporated into a cassette vector (N5LG1) containing human constant region genes and subsequently transfected into the Dg44 CHO cell line
- AccessionP33681
- Gene Id941
- AppearanceColorless liquid
- FormLiquid
- Concentration1 mg/ml
- FormulationIn PBS with 0.02% Proclin 300
- PurificationProtein A affinity purified
- ApplicationBlock, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting, Modulate, Flow Cytometry, ELISA
- Application And UsagesWB, ELISA, IP, IF, IHC, FC, Block, Modulate
- DescriptionGaliximab is a primatized mAb which consists of human constant and primate (cynomolgus macaque) variable regions and binds specifically to CD80. CD80 is a surface glycoprotein and a member of the B7 family of co-stimulatory molecules. CD80 antigen regulates T cell activation (through interacting with CD28 or CD152) and is expressed transiently in antigen-presenting cells, T cells and normal B cells, and expressed constitutively on various subtypes of B-cell lymphomas. Galiximab acts to decrease in cell proliferation, inhibition of the constitutively active NF-κB pathway, increase in apoptosis and ADCC against various B-cell lymphoma cell lines. Galiximab affects CD28 and CD152 interactions with CD80.
- Storage Condition-20ºC
- Shipping ConditionGel Pack
- Shelf Life12 months
- UsageFor Research Use Only! Not to be used in humans.
- HandlingThe antibody solution should be gently mixed before use.
- Western Blot VerifiedFalse
- Immunocytochemistry VerifiedFalse
- Immunofluorescence VerifiedTrue
- Immunoprecipitation VerifiedFalse
- FACS VerifiedFalse
- ELISA VerifiedFalse
- ChIP VerifiedFalse
- Dot Blot VerifiedFalse
- Flow Cytometry VerifiedFalse
- Data Sheet Link
- Alternative to gene target
- [ "CD80 molecule", "B7 and B7-1 and B7.1 and BB1 and CD28LG and CD28LG1 and LAB7", "CD80 and IDBG-51287 and ENSG00000121594 and 941", "coreceptor activity", "Cell surfaces", "Cd80 and IDBG-160288 and ENSMUSG00000075122 and 12519", "BT.27986 and IDBG-632750 and ENSBTAG00000018059 and 407131" ]
- Gene targetCD80 Galiximab IgG1 lambda
- Identity:HGNC:1700
- Gene:CD80
- Long gene name:CD80 molecule
- Synonyms gene name:CD80 antigen (CD28 antigen ligand 1, B7-1 antigen), CD80 molecule
- Synonyms:B7.1, B7-1
- Discovery year:1993-12-14
- Entrez gene record:941
- Pubmed identification:1370389
- RefSeq identity:NM_005191
- Classification:B7 family, CD molecules, C2-set domain containing, V-set domain containing
- VEGA ID:OTTHUMG00000159419
- Gene symbolCD80
- isotype filter
- Human IgG1
- lambda
- Short nameAnti-CD80 (Galiximab), IgG1, lambda Antibody
- technique filter
- Antibody
- anti-
- anti
- TechniqueAntibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
- Alternative techniqueantibodies