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Anti-CD11c Antibody (ITGAX/1243)

  • Catalog number
    A1474-100
  • Product name
    Anti-CD11c Antibody (ITGAX/1243)
  • Size
    100 µg
  • Antibody Target
    CD11c
  • Target Alternative Name
    CD11 antigen-like family member C; Complement component 3 receptor 4 subunit; Integrin alpha-X; integrin, alpha X (antigen CD11C (p150), alpha polypeptide); Leu M5 alpha subunit; Leukocyte adhesion glycoprotein p150 95 alpha chain; Myeloid membrane antigen alpha subunit; p150/95
  • Antibody Type
    Monoclonal
  • Clone
    ITGAX/1243
  • Isotype
    Mouse IgG2b, kappa
  • Species Reactivities
    Human
  • Immunogen Sequence
    Recombinant human ITGAX protein fragment (aa 637-827)
  • Accession
    P20702
  • Gene Id
    3687
  • Appearance
    Colorless liquid
  • Form
    Liquid
  • Formulation
    In 10 mM PBS with 0.05% BSA & 0.05% azide
  • Purification
    Protein A/G purification
  • Application
    FC, IF, IHC
  • Positive Control
    IHC: human Prostate Carcinoma, human Lung Carcinoma, human Follicular Lymphoma
  • Application And Usages
    FC: 0.5-1 ug/1X106 cells, IF: 0.5-1 ug/ml, IHC: 1-2 ug/ml
  • Description
    Recognizes a protein of 145kDa, identified as CD11c. CD11c (ITGAX), a member of the leukointegrin family, shares the same beta subunit with other members of the leukocyte adhesion molecule family, which includes CD11a (LFA-1), CD11b (MAC-1) and CD11d (ITGAD), but has a unique alpha chain. CD11c has been shown to play a role in phagocytosis, cell migration, and cytokine production by monocytes/macrophages as well as induction of T-cell proliferation by Langerhans cells. CD11c is expressed prominently on the plasma membranes of monocytes, tissue macrophages, NK cells, and most dendritic cells (DCs). A lower level of expression is also observed on neutrophils as a result of its high level of expression on most DCs. An antibody to CD11c may aid in identification of lesions with histiocytic origin. It may also been used as a marker for hairy cell leukemia in paraffin-embedded tissues.
  • Storage Condition
    -20 °C
  • Shipping Condition
    gel pack
  • Shelf Life
    12 months
  • Usage
    For Research Use Only! Not to be used in humans
  • Handling
    The antibody solution should be gently mixed before use
  • Western Blot Verified
    Not Verified
  • Immunocytochemistry Verified
    Verified
  • Immunofluorescence Verified
    Not Verified
  • Immunoprecipitation Verified
    Not Verified
  • FACS Verified
    Not Verified
  • ELISA Verified
    Not Verified
  • ChIP Verified
    Not Verified
  • Dot Blot Verified
    Not Verified
  • Flow Cytometry Verified
    Not Verified
  • Data Sheet Link
    Data_Sheet_Link
  • Alternative to gene target
    • [ "integrin, alpha X (complement component 3 receptor 4 subunit)", "CD11C and SLEB6", "ITGAX and IDBG-28212 and ENSG00000140678 and 3687", "metal ion binding", "Cell surfaces", "Itgax and IDBG-210550 and ENSMUSG00000030789 and 16411" ]
  • Gene target
    CD11c ITGAX/1243
    • Gene info
  • Gene symbol
    ITGAX
  • isotype filter
    • Mouse IgG2b
    • kappa
  • Short name
    Anti-CD11c Antibody (ITGAX/1243)
  • technique filter
    • Antibody
    • anti-
    • anti
  • Technique
    Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
  • Alternative technique
    antibodies