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Anti-Bcl-6 Antibody (BCL6/1527)

  • Catalog number
    A1437-100
  • Product name
    Anti-Bcl-6 Antibody (BCL6/1527)
  • Size
    100 µg
  • Antibody Target
    BCL6
  • Target Alternative Name
    B-cell lymphoma 5 protein, B-Cell Lymphoma 6 Protein, BCL5, BCL6, BCL6A, cys his2 zinc finger transcription factor, Lymphoma Associated Zinc Finger Gene On Chromosome 3 (LAZ3), Zinc finger and BTB domain-containing protein 27 (ZBTB27), Zinc Finger Protein 51 (ZNF51), zinc finger transcription factor BCL6S
  • Antibody Type
    Monoclonal
  • Clone
    BCL6/1527
  • Isotype
    Mouse IgG1, kappa
  • Species Reactivities
    Human
  • Immunogen Sequence
    Recombinant human bcl-6 protein fragment (aa 256-389)
  • Accession
    P41182
  • Gene Id
    604
  • Appearance
    Colorless liquid
  • Form
    Liquid
  • Formulation
    In 10 mM PBS with 0.05% BSA & 0.05% azide
  • Purification
    Protein A/G purification
  • Application
    FC, IF, IHC
  • Positive Control
    IHC: Human tonsil
  • Application And Usages
    FC: 0.5-1 ug/1X106 cells, IF: 1-2 ug/ml, IHC: 1-2 ug/ml
  • Description
    Recognizes a protein of 95 kDa, which is identified as Bcl-6. Antibody to bcl-6 is helpful in a number of diagnostic settings: (1) In the differential diagnosis of small B-cell lymphoma. Follicular lymphoma will show bcl-6 (and CD10) positivity whereas other small B-cell lymphomas are usually negative. (2) Bcl-6 is an important prognostic marker in diffuse large B-cell lymphomas (DLBCL), where CD10, bcl-6 and MUM1/IRF4 are used to identify germinal center and activated B-cell phenotypes. (3) Bcl-6 can be valuable in distinguishing classical Hodgkin lymphoma from nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). The Reed-Sternberg cells of classical Hodgkin lymphoma are bcl-6 negative whereas the large (L&H) cells of NLPHL are bcl-6 positive. In contrast, anti-Bcl-6 rarely stains mantle-cell lymphoma and MALT lymphoma.
  • Storage Condition
    -20°C
  • Shipping Condition
    gel pack
  • Shelf Life
    12 months
  • Usage
    For Research Use Only! Not to be used in humans.
  • Handling
    The antibody solution should be gently mixed before use.
  • Western Blot Verified
    Not Verified
  • Immunocytochemistry Verified
    Verified
  • Immunofluorescence Verified
    Not Verified
  • Immunoprecipitation Verified
    Not Verified
  • FACS Verified
    Not Verified
  • ELISA Verified
    Not Verified
  • ChIP Verified
    Not Verified
  • Dot Blot Verified
    Not Verified
  • Flow Cytometry Verified
    Not Verified
  • Data Sheet Link
    Data_Sheet_Link
  • Alternative to gene target
    • [ "B-cell CLL/lymphoma 6", "BCL5 and BCL6A and LAZ3 and ZBTB27 and ZNF51", "BCL6 and IDBG-69349 and ENSG00000113916 and 604", "metal ion binding", "nuclei", "Bcl6 and IDBG-149890 and ENSMUSG00000022508 and 12053", "BCL6 and IDBG-634562 and ENSBTAG00000001511 and 539020" ]
  • Gene target
    Bcl-6 BCL6/1527
    • Gene info
    Gene info
  • Gene symbol
    BCL6-AS1, BCL6
  • isotype filter
    • Mouse IgG1
    • kappa
  • Short name
    Anti-Bcl-6 Antibody (BCL6/1527)
  • technique filter
    • Antibody
    • anti-
    • anti
  • Technique
    Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
  • Alternative technique
    antibodies