- Catalog numberA2171-100
- Product nameAnti-ANGPTL3 (Evinacumab), Human IgG4 Antibody
- Size100 µg
- PriceAsk For Price
- Antibody TargetANGPTL3
- Target Alternative NameREGN 1500, REGN1500, ANL3, ANG-5, FHBL2, ANGPT5
- Antibody TypeMonoclonal
- IsotypeIgG4, kappa
- Species ReactivitiesHuman
- Immunogen SequenceHuman ANGPTL3
- AccessionDB15354
- AppearanceColorless liquid
- FormLiquid
- Concentration1 mg/ml
- FormulationIn PBS, pH 7.5
- PurificationProtein A purified
- DescriptionThe research-grade biosimilar is an investigational human monoclonal antibody that targets angiopoietin-like 3 inhibitor (ANGPTL3). ANGPTL3 is primarily expressed in the liver and it inhibits LPL activity and endothelial lipase activity. This prevents the clearance of lipids and raises the concentration of triglycerides and LDL-C in the blood. The antibody binds with high affinity and specificity to ANGPTL3 and reverses the inhibitory action on LPL, thus promoting the clearance of LDL-C from the blood. The original drug was awarded breakthrough therapy designation by the FDA to treat patients suffering from homozygous familial hypercholesterolemia (HoFH).
- Storage Condition-80ºC
- Shipping ConditionGel Pack
- Shelf Life12 months
- UsageFor Research Use Only! Not to be used in humans.
- HandlingThe antibody solution should be gently mixed before use.
- Western Blot Verified0
- Immunocytochemistry Verified0
- Immunofluorescence Verified0
- Immunoprecipitation Verified0
- FACS Verified0
- ELISA Verified0
- ChIP Verified0
- Dot Blot Verified0
- Flow Cytometry Verified0
- Data Sheet Link
- Alternative to gene target
- [ "angiopoietin-like 3", "ANGPTL3 and IDBG-99367 and ENSG00000132855 and 27329", "growth factor activity", "Extracellular", "Angptl3 and IDBG-166252 and ENSMUSG00000028553 and 30924", "ANGPTL3 and IDBG-638594 and ENSBTAG00000021386 and 782603" ]
- Gene targetANGPTL3 Evinacumab IgG4
- Identity:HGNC:491
- Gene:ANGPTL3
- Long gene name:angiopoietin like 3
- Synonyms gene name:angiopoietin-like 3
- Discovery year:2000-02-07
- Entrez gene record:27329
- Pubmed identification:10644446
- RefSeq identity:NM_014495
- Classification:Fibrinogen C domain containing, Receptor ligands, Angiopoietin like family
- VEGA ID:OTTHUMG00000009146
- Gene symbolANGPTL3
- isotype filter
- IgG4
- kappa
- Short nameAnti-ANGPTL3 (Evinacumab), IgG4 Antibody
- technique filter
- Antibody
- anti-
- anti
- TechniqueAntibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
- Alternative techniqueantibodies