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Akt Inhibitor, Isozyme-Selective

  • Catalog number
    1708-1
  • Product name
    Akt Inhibitor, Isozyme-Selective
  • Size
    1 mg
  • Description
    Cell-permeable. A potent and selective inhibitor of Akt1/Akt2 activity (IC₅₀ = 58 nM (Akt1), 210 nM (Akt2) and 2.12 µM (Akt3) in in vitro kinase assays). The inhibition appears to be pleckstrin homology (PH) domain-dependent. It does not exhibit any inhibitory effect against PH domain-lacking Akts, or other closely related AGC family kinases, PKA, PKC, and SGK, even at concentrations (50 µM).
  • CAS Number
    612847-09-3
  • Structure Available
    Yes
  • Salt Form
    No
  • Molecular Formula
    C₃₄H₂₉N₇O
  • Molecular Weight
    551.65
  • Cell Permeable
    Yes
  • Purity
    ≥97% by HPLC
  • Solubilities
    DMSO
  • Handling
    Protect from air and moisture
  • Tag Line
    An Akt inhibitor
  • Storage Condition
    -20°C
  • Shipping Condition
    gel pack
  • Shelf Life
    24 months
  • MDL Number
    MFCD08705407
  • PubChem CID
    10196499
  • PubChem CID Link
    PubChem_CID_Link
  • SMILES
    C1CN(CCC1N2C3=CC=CC=C3NC2=O)CC4=CC=C(C=C4)C5=NC6=CC7=C(C=C6N=C5C8=CC=CC=C8)N=CN7
  • InChi
    InChI=1S/C34H29N7O/c42-34-39-26-8-4-5-9-31(26)41(34)25-14-16-40(17-15-25)20-22-10-12-24(13-11-22)33-32(23-6-2-1-3-7-23)37-29-18-27-28(36-21-35-27)19-30(29)38-33/h1-13,18-19,21,25H,14-17,20H2,(H,35,36)(H,39,42)
  • InChi Key
    BIWGYFZAEWGBAL-UHFFFAOYSA-N
  • Data Sheet Link
    Data_Sheet_Link
  • MSDS Available
    Yes
  • Gene target
    Akt Inhibitor Isozyme-Selective
  • Short name
    Akt Inhibitor, Isozyme-Selective