XAF1 Antibody

• Catalog number
  bs-1308R
• Price
  Please ask
• Size
  0.1ml

• Long name
  XAF1 Primary Polyclonal Antibody
• Also known as
  XAF1 PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  XAF1
• Specificity
  This is a highly specific antibody against XAF1.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  170-220/273
• Subcellular location
  Cytoplasm, Nucleus, Mitochondrion
• Source
  KLH conjugated synthetic peptide derived from mouse XAF1
• Gene ID number
  327959
• Swiss Prot
  Q5NBU8
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti-caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha-induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondra, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm. The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin; the process requires the E3 ligase activity of BIRC4. Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL. May be a tumor suppressor by mediating apoptosis resistance of cancer cells (By similarity).
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  Fbox39; XIAP-associated factor 1; BIRC4-binding protein; Xaf1; Birc4bp; Xiapaf1
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  XAF1  
• Gene symbol
  XAF1
• Short name
  Anti-XAF1
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  XAF1 Polyclonal Antibody
• Alternative technique
  antibodies
• Alternative to gene target
  XIAP associated factor 1, XAF1 and IDBG-22619 and ENSG00000132530 and 54739, zinc ion binding, nuclei, Xaf1 and IDBG-196515 and ENSMUSG00000040483 and 327959, XAF1 and IDBG-633696 and ENSBTAG00000011343 and 509740

Gene info

• Identity
  HGNC:30932
• Gene
  XAF1
• Long gene name
  XIAP associated factor 1
• Synonyms
  • BIRC4BP
  • XIAPAF1
  • HSXIAPAF1
• GenBank acession
  • X99699
• Locus
  17p13.2
• Discovery year
  2008-03-04
• Entrez gene record
  54739
• Pubmed identfication
  • 12029096
  • 11175744
• RefSeq identity
  • NM_017523
• VEGA ID
  OTTHUMG00000177908

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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