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Syk (8H5) Monoclonal Antibody

  • Catalog number
    bsm-50292M
  • Product name
    Syk (8H5) Monoclonal Antibody
  • Size
    0.1ml
  • Short name
    Anti-Syk
  • Long name
    Syk (8H5) Monoclonal Antibody
  • Also known as
    Syk (8H5) Monoclonal Antibody
  • Category
    Primary Antibodies
  • Conjugation
    Unconjugated
  • Host
    Mouse (Mus musculus)
  • Target Antigen
    Syk
  • Specificity
    This is a highly specific antibody against Syk.
  • Modification s
    None
  • Modification site s
    Unmodified antibody
  • Clonality
    Monoclonal
  • Clone number
    8H5
  • Isotype
    Immunoglobulin G (IgG)1 κ
  • Source
    Synthetic peptide
  • Gene ID number
    6850
  • Swiss Prot
    P43405
  • Tested Applications
    IP
  • Recommended dilutions
    IP (2 ul)
  • Cross reactivity
    Human
  • Cross reactive species details
    Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
  • Background of the target antigen
    Syk, Spleen tyrosine kinase, is expressed in a wide range of hematopoietic and non-hematopoietic cells and plays a key role in adaptive immune system, which is the immunoreceptor (B cell receptor and Fc-receptors) signaling pathways including Fcγ receptor-mediated phagocytosis. In hematopoietic cells such as B and T lymphocytes, natural killer cells, mast cells, macrophages and platelets, Syk is involved in the proximal signaling downstream of activated immunoreceptors (e.g. BCR, TCR, Fc receptors) containing immunoreceptor tyrosine-based activation motifs (ITAMs) to which it binds using its tandem SH2 domains. Activated and autophosphorylated Syk then phosphorylates its specific substrates including other enzymes and adaptor proteins, orchestrating a complex series of cellular responses such as cell proliferation, differentiation, survival and phagocytosis.
  • Purification method
    Ammonium sulfate precipitation
  • Storage conditions
    Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
  • Synonym names
    p72-Syk; Tyrosine-protein kinase SYK; Spleen tyrosine kinase; SYK
  • Alternative to gene target
    • [ "spleen tyrosine kinase", "p72-Syk", "SYK and IDBG-75571 and ENSG00000165025 and 6850", "transferase activity", "Plasma membranes", "Syk and IDBG-152695 and ENSMUSG00000021457 and 20963", "SYK and IDBG-637026 and ENSBTAG00000004767 and 515515" ]
  • Gene target
    Syk 8H5 Monoclonal
  • isotype filter
    • Immunoglobulin G IgG 1 κ
  • technique filter
    • Antibody
  • Technique
    Antibody, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies
  • Alternative technique
    antibodies