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HER2 (Tyr877) Antibody

  • Catalog number
    bs-2896R
  • Product name
    HER2 (Tyr877) Antibody
  • Size
    0.1ml
  • Short name
    Anti-HER2 Tyr877
  • Long name
    HER2 (Tyr877) Primary Polyclonal Antibody
  • Also known as
    HER2 (Tyr877) PAb
  • Category
    Primary Antibodies
  • Conjugation
    Unconjugated
  • Host
    Rabbit (Oryctolagus cuniculus)
  • Target Antigen
    HER2 Tyr877
  • Specificity
    This is a highly specific antibody against HER2 Tyr877.
  • Modification s
    Phosphorylation
  • Modification site s
    Tyr877
  • Clonality
    Polyclonal antibody
  • Clone number
    Polyclonal antibody
  • Isotype
    Immunoglobulin G (IgG)
  • Concentration
    1ug per 1ul
  • Source
    KLH conjugated synthetic phosphopeptide derived from human HER2 around the phosphorylation site of Tyr877
  • Gene ID number
    2064
  • Tested Applications
    WB, IHC-P, IF(IHC-P)
  • Recommended dilutions
    WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
  • Cross reactivity
    Human, Mouse, Rat
  • Cross reactive species details
    Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
  • Background of the target antigen
    This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008].
  • Purification method
    This antibody was purified via Protein A.
  • Storage conditions
    Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
  • Synonym names
    ErbB 2 phospho Y877; p-ErbB 2 phospho Y877; HER2Tyr877; CerbB2; c erb B2; C erbB 2; C-erbB2; CD340; CD340 antigen; Cerb B2/neu protein; Erb B2; erbb2; HER 2; HER 2/neu; HER2; Her2/neu; Herstatin; MLN 19; MLN19; NEU; NEU Proto Oncogene; Neuro Glioblastoma Derived Oncogene Homolog; Neuroblastoma/glioblastoma derived oncogene homolog; NGL; p185 ErbB2; p185erbB2; Receptor Protein Tyrosine Kinase ErbB2 Precursor; Receptor tyrosine protein kinase erbB 2; TKR1.
  • Gene target
    HER2 Tyr877
    • Gene info
    Locus Specific Databases:LRG_724
  • Gene symbol
    ERBB2
  • isotype filter
    • Immunoglobulin G IgG
  • technique filter
    • Antibody
  • Technique
    Antibody, antibodies against human proteins, antibodies for
  • Alternative technique
    antibodies