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UNC5H3/UNC5C Antibody, Cy3 Conjugated

  • Catalog number
    bs-11493R-Cy3
  • Product name
    UNC5H3/UNC5C Antibody, Cy3 Conjugated
  • Size
    0.1ml
  • Short name
    Anti-UNC5H3/UNC5C
  • Long name
    UNC5H3/UNC5C Polyclonal Antibody, Cy3 Conjugated
  • Category
    Conjugated Primary Antibodies
  • Conjugation
    Cy3
  • Host Organism
    Rabbit (Oryctolagus cuniculus)
  • Target Antigen
    UNC5H3/UNC5C
  • Specificity
    This is a highly specific antibody against UNC5H3/UNC5C.
  • Modification
    Unmodified
  • Modification site
    None
  • Clonality
    Polyclonal
  • Clone
    Polyclonal antibody
  • Isotype
    Immunoglobulin G (IgG)
  • Concentration
    1ug per 1ul
  • Subcellular location
    Extracellular
  • Source
    KLH conjugated synthetic peptide derived from human UNC5H3
  • Tested applications
    FCM, IF(IHC-P)
  • Recommended dilutions
    FCM(1:20-100), IF(IHC-P)(1:50-200)
  • Crossreactivity
    Human, Mouse, Rat
  • Crossreactive species details
    Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
  • Antigen background
    The UNC5H family of proteins act as transmembrane receptors for netrin-1 and play a crucial role in axon guidance and migration of neural cells. Additionally, UNC5H receptors induce apoptosis when cleaved by a caspase, producing an intracellular fragment containing a death domain. This activity is blocked by the binding of netrin-1. In the absence of netrin-1, UNC5H receptors act as tumor suppressors by inhibiting anchorage-independent growth and invasion, but mutation of these receptors provides a potential mechanism for tumorigenicity. The expression of UNC5H receptors is down-regulated in multiple cancers, including colorectal, breast, ovary, uterus, stomach, lung, and kidney cancers. UNC5H3, also known as UNC5C, plays an important role in the development of spinal accessory motor neurons. It is also involved in mediating the repulsive action for netrin-1 and it serves as a stop signal for migratory cells.
  • Purification method
    This antibody was purified via Protein A.
  • Storage conditions
    Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
  • Excitation Emission
    512,550nm/570,615nm
  • Synonyms
    Alternative nameshomolog of C. elegans transmembrane receptor Unc5; Netrin receptor UNC5C; Protein unc 5 homolog C; Unc 5 homolog 3; Unc 5 homolog C; Unc5 C.elegans homolog c; UNC5H3; UNC5C_HUMAN.
  • Alternative to gene target
    • [ "unc-5 homolog C (C. elegans)", "UNC5H3", "UNC5C and IDBG-30714 and ENSG00000182168 and 8633", "protein binding", "Plasma membranes", "Unc5c and IDBG-196891 and ENSMUSG00000059921 and 22253", "UNC5C and IDBG-640984 and ENSBTAG00000002084 and 533256" ]
  • Gene target
    UNC5H3/UNC5C Conjugated
    • Gene info
    Gene info
    • Identity:HGNC:55246
    • Gene:UNC5C-AS1
    • Long gene name:UNC5C antisense RNA 1
    • Discovery year:2020-09-17
    • Entrez gene record:105377335
    • Classification:Antisense RNAs
  • Gene symbol
    UNC5C, UNC5C-AS1
  • isotype filter
    • Immunoglobulin G IgG
  • Label
    Cy3
  • label filter
    • Cy3
  • technique filter
    • Antibody
  • Technique
    Antibody, antibodies against human proteins, antibodies for, antibody Conjugates
  • Alternative technique
    antibodies