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Ubiquitin D Antibody, Biotin Conjugated

  • Catalog number
    bs-13006R-Biotin
  • Product name
    Ubiquitin D Antibody, Biotin Conjugated
  • Size
    0.1ml
  • Short name
    Anti-Ubiquitin D
  • Long name
    Ubiquitin D Polyclonal Antibody, Biotin Conjugated
  • Category
    Conjugated Primary Antibodies
  • Conjugation
    Biotin
  • Host Organism
    Rabbit (Oryctolagus cuniculus)
  • Target Antigen
    Ubiquitin D
  • Specificity
    This is a highly specific antibody against Ubiquitin D.
  • Modification
    Unmodified
  • Modification site
    None
  • Clonality
    Polyclonal
  • Clone
    Polyclonal antibody
  • Isotype
    Immunoglobulin G (IgG)
  • Concentration
    1ug per 1ul
  • Immunogen range
    60-100/165
  • Subcellular location
    Cytoplasm, Nucleus
  • Source
    KLH conjugated synthetic peptide derived from human Ubiquitin D
  • Gene ID number
    10537
  • Swiss Prot
    O15205
  • Tested applications
    WB, IHC-P
  • Recommended dilutions
    WB(1:100-1000), IHC-P(1:100-500)
  • Crossreactivity
    Human, Mouse, Rat
  • Crossreactive species details
    Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
  • Antigen background
    Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently leads to their degradation by the 26S proteasome, in a NUB1L-dependent manner. Probably functions as a survival factor. Conjugation ability activated by UBA6. Promotes the expression of the proteasome subunit beta type-9 (PSMB9/LMP2). Regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha. Required for TNF-alpha-induced p65 nuclear translocation in renal tubular epithelial cells (RTECs). May be involved in dendritic cell (DC) maturation, the process by which immature dendritic cells differentiate into fully competent antigen-presenting cells that initiate T-cell responses. Mediates mitotic non-disjunction and chromosome instability, in long-term in vitro culture and cancers, by abbreviating mitotic phase and impairing the kinetochore localization of MAD2L1 during the prometaphase stage of the cell cycle. May be involved in the formation of aggresomes when proteasome is saturated or impaired. Mediates apoptosis in a caspase-dependent manner, especially in renal epithelium and tubular cells during renal diseases such as polycystic kidney disease and Human immunodeficiency virus (HIV)-associated nephropathy (HIVAN).
  • Purification method
    This antibody was purified via Protein A.
  • Storage conditions
    Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
  • Excitation Emission
    N/A
  • Synonyms
    FAT10; UBD-3; GABBR1; Ubiquitin D; Diubiquitin; Ubiquitin-like protein FAT10; UBD
  • Gene target
    Ubiquitin D Conjugated
  • isotype filter
    • Immunoglobulin G IgG
  • Label
    Biotin
  • label filter
    • Biotin
  • technique filter
    • Antibody
  • Technique
    Antibody, antibodies against human proteins, antibodies for, antibody Conjugates
  • Alternative technique
    antibodies