- Catalog numberbs-10656R-FITC
- Product namePI3 Kinase p110 delta antibody, FITC Conjugated
- Size0.1ml
- PriceAsk For Price
- Short nameAnti-PI3 Kinase p110 delta
- Long namePI3 Kinase p110 delta antibody, FITC Conjugated
- CategoryConjugated Primary Antibodies
- ConjugationFITC
- Host OrganismRabbit (Oryctolagus cuniculus)
- Target AntigenPI3 Kinase p110 delta
- SpecificityThis is a highly specific antibody against PI3 Kinase p110 delta.
- ModificationUnmodified
- Modification siteNone
- ClonalityPolyclonal
- ClonePolyclonal antibody
- IsotypeImmunoglobulin G (IgG)
- Concentration1ug per 1ul
- SourceKLH conjugated synthetic peptide derived from human PI3 Kinase p110 delta
- Gene ID number5293
- Tested applicationsIF(IHC-P)
- Recommended dilutionsIF(IHC-P)(1:50-200)
- CrossreactivityHuman, Mouse, Rat
- Crossreactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
- Antigen backgroundPhosphoinositide-3-kinase (PI3K) that phosphorylates PftdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Mediates immune responses. Plays a role in B-cell development, proliferation, migration, and function. Required for B-cell receptor (BCR) signaling. Mediates B-cell proliferation response to anti-IgM, anti-CD40 and IL4 stimulation. Promotes cytokine production in response to TLR4 and TLR9. Required for antibody class switch mediated by TLR9. Involved in the antigen presentation function of B-cells. Involved in B-cell chemotaxis in response to CXCL13 and sphingosine 1-phosphate (S1P). Required for proliferation, signaling and cytokine production of naive, effector and memory T-cells. Required for T-cell receptor (TCR) signaling. Mediates TCR signaling events at the immune synapse. Activation by TCR leads to antigen-dependent memory T-cell migration and retention to antigenic tissues. Together with PIK3CG participates in T-cell development. Contributes to T-helper cell expansion and differentiation. Required for T-cell migration mediated by homing receptors SELL/CD62L, CCR7 and S1PR1 and antigen dependent recruitment of T-cells. Together with PIK3CG is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in NK cell receptor activation. Have a role in NK cell maturation and cytokine production. Together with PIK3CG is involved in neutrophil chemotaxis and extravasation. Together with PIK3CG participates in neutrophil respiratory burst. Have important roles in mast-cell development and mast cell mediated allergic response. Involved in stem cell factor (SCF)-mediated proliferation, adhesion and migration.
- Purification methodThis antibody was purified via Protein A.
- Storage conditionsKeep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
- Excitation Emission494nm/518nm
- Synonymsp110D; p110delta; Phosphatidylinositol 3 kinase catalytic delta polypeptide; Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit delta isoform; Phosphatidylinositol 45 bisphosphate 3 kinase catalytic subunit delta isoform;
- Gene targetPI3 Kinase p110 delta Conjugated
- Identity:HGNC:8947
- Gene:PI3
- Long gene name:peptidase inhibitor 3
- Synonyms gene name:protease inhibitor 3, skin-derived (SKALP), peptidase inhibitor 3, skin-derived
- Synonyms:ESI, SKALPELAFINWAP3WFDC14cementoin
- Discovery year:1993-07-27
- Entrez gene record:5266
- Pubmed identification:8287685, 12206714
- RefSeq identity:NM_002638
- Classification:WAP four-disulfide core domain containing
- VEGA ID:OTTHUMG00000032567
- Gene symbolPI3
- isotype filter
- Immunoglobulin G IgG
- LabelFITC
- label filter
- FITC
- technique filter
- Antibody
- FITC
- TechniqueAntibody, FITC, antibodies against human proteins, antibodies for, antibody Conjugates, Fluorescein
- Alternative techniqueantibodies, fluorescine