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P53(Ser392) Antibody, FITC Conjugated

  • Catalog number
    bs-1650R-FITC
  • Product name
    P53(Ser392) Antibody, FITC Conjugated
  • Size
    0.1ml
  • Short name
    Anti-P53 Ser392
  • Long name
    P53(Ser392) Polyclonal Antibody, FITC Conjugated
  • Category
    Conjugated Primary Antibodies
  • Conjugation
    FITC
  • Host Organism
    Rabbit (Oryctolagus cuniculus)
  • Target Antigen
    P53 Ser392
  • Specificity
    This is a highly specific antibody against P53 Ser392.
  • Modification
    Phosphorylation
  • Modification site
    Ser392
  • Clonality
    Polyclonal
  • Clone
    Polyclonal antibody
  • Isotype
    Immunoglobulin G (IgG)
  • Concentration
    1ug per 1ul
  • Immunogen range
    382-393/393
  • Source
    KLH conjugated synthetic phosphopeptide derived from human p53 around the phosphorylation site of (Ser392)
  • Gene ID number
    7157
  • Swiss Prot
    P04637
  • Tested applications
    IF(IHC-P)
  • Recommended dilutions
    IF(IHC-P)(1:50-200)
  • Crossreactivity
    Human
  • Crossreactive species details
    Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
  • Antigen background
    Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.
  • Purification method
    This antibody was purified via Protein A.
  • Storage conditions
    Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
  • Excitation Emission
    494nm/518nm
  • Synonyms
    P53; BCC7; LFS1; TRP53; Cellular tumor antigen p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53; TP53
  • Gene target
    P53 Ser392 Conjugated
    • Gene info
    Locus Specific Databases:IARC TP53 Mutation Databasep53 UMD TP53 mutation databaseDatabase of Germline p53 MutationsMUTP53LOAD, Mutant p53 Loss Of Activity DatabaseLRG_321
  • Gene symbol
    TP53
  • isotype filter
    • Immunoglobulin G IgG
  • Label
    FITC
  • label filter
    • FITC
  • technique filter
    • Antibody
    • FITC
  • Technique
    Antibody, FITC, antibodies against human proteins, antibodies for, antibody Conjugates, Fluorescein
  • Alternative technique
    antibodies, fluorescine