- Catalog numberbs-10180R-Cy3
- Product nameAdeno-Associated Virus Capsid Protein VP1 Antibody, Cy3 Conjugated
- Size0.1ml
- PriceAsk For Price
- Short nameAnti-Adeno-Associated Virus Capsid Protein VP1
- Long nameAdeno-Associated Virus Capsid Protein VP1 Antibody, Cy3 Conjugated
- CategoryConjugated Primary Antibodies
- ConjugationCy3
- Host OrganismRabbit (Oryctolagus cuniculus)
- Target AntigenAdeno-Associated Virus Capsid Protein VP1
- SpecificityThis is a highly specific antibody against Adeno-Associated Virus Capsid Protein VP1. This antibody will recognize many AAV strains, including AAV5, AAV4, AAV3B, AAV9, and AAV13
- ModificationUnmodified
- Modification siteNone
- ClonalityPolyclonal
- ClonePolyclonal antibody
- IsotypeImmunoglobulin G (IgG)
- Concentration1ug per 1ul
- Immunogen range30-80/724
- SourceKLH conjugated synthetic peptide derived from Adeno-Associated Virus 5 capsid protein VP1
- Tested applicationsIF(IHC-P)
- Recommended dilutionsIF(IHC-P)(1:50-200)
- CrossreactivityVirus
- Crossreactive species detailsAAV5
- Antigen backgroundCapsid protein self-assembles to form an icosahedral capsid with a T=1 symmetry, about 22 nm in diameter, and consisting of 60 copies of three size variants of the capsid protein VP1, VP2 and VP3 which differ in their N-terminus. The capsid encapsulates the genomic ssDNA. Binds to host cell heparan sulfate and uses host ITGA5-ITGB1 as coreceptor on the cell surface to provide virion attachment to target cell. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Binding to the host receptor also induces capsid rearrangements leading to surface exposure of VP1 N-terminus, specifically its phospholipase A2-like region and putative nuclear localization signal(s). VP1 N-terminus might serve as a lipolytic enzyme to breach the endosomal membrane during entry into host cell and might contribute to virus transport to the nucleus
- Purification methodThis antibody was purified via Protein A.
- Storage conditionsKeep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
- Excitation Emission512,550nm/570,615nm
- Synonymscapsid protein Adeno-associated 5 virus; capsid protein [Adeno-associated virus - 5]; capsid protein AAV5; Parvovirus coat protein VP1; capsid protein.
- Gene targetAdeno-Associated Virus Capsid Protein VP1 Conjugated
- isotype filter
- Immunoglobulin G IgG
- LabelCy3
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- Cy3
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- Antibody
- TechniqueAntibody, antibodies against human proteins, antibodies for, antibody Conjugates
- Alternative techniqueantibodies