- Catalog numberbs-2941R-A647
- Product nameTNF Receptor I Antibody, ALEXA FLUOR 647
- Size100ul
- PriceAsk For Price
- Short nameAnti-TNFR1
- Long nameTNF Receptor I Polyclonal Antibody, ALEXA FLUOR 647 Conjugated
- Also known asAnti-TNFR1 PAb ALEXA FLUOR 647
- CategoryConjugated Primary Antibodies
- Conjugated withALEXA FLUOR® 647
- Host OrganismRabbit (Oryctolagus cuniculus)
- Target AntigenTNFR1
- SpecificityThis is a highly specific antibody against TNFR1.
- ModificationUnmodified
- Modification SiteNone
- ClonalityPolyclonal
- ClonePolyclonal antibody
- IsotypeImmunoglobulin G (IgG)
- Concentration1ug per 1ul
- Immunogen range22-72/455
- Subcellular locationExtracellular, Cell membrane
- SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human TNF Receptor I
- Gene ID Number7132
- Swiss ProtP19438
- Tested applicationsIF(IHC-P)
- Recommended dilutionsIF(IHC-P)(1:50-200)
- CrossreactivityHuman, Mouse, Rat
- Cross reactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
- Background of the antigenReceptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
- PurificationPurified by Protein A.
- Storage conditionsStore this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
- Excitation emission650nm/665nm
- SynonymsTumor necrosis factor receptor superfamily member 1A; Tumor necrosis factor receptor 1; TNF-R1; Tumor necrosis factor receptor type I; TNF-RI; TNFR-I; p55; p60; CD120a; TNFRSF1A; TNFAR; TNFR1
- Alternative to gene target
- [ "tumor necrosis factor", "DIF and TNF-alpha and TNFA and TNFSF2", "TNF and IDBG-300259 and ENSG00000232810 and 7124", "transcription regulatory region DNA binding", "Extracellular", "Tnf and IDBG-177358 and ENSMUSG00000024401 and 21926", "TNF and IDBG-634161 and ENSBTAG00000025471 and 280943" ]
- Gene targetTNF Receptor I
- Identity:HGNC:11892
- Gene:TNF
- Long gene name:tumor necrosis factor
- Synonyms gene name:tumor necrosis factor (TNF superfamily, member 2)
- Synonyms:TNFSF2DIFTNF-alpha
- Discovery year:1986-01-01
- Entrez gene record:7124
- Pubmed identification:2413547, 6392892
- Classification:Tumor necrosis factor superfamily
- VEGA ID:OTTHUMG00000031194
- Identity:HGNC:11916
- Gene:TNFRSF1A
- Long gene name:TNF receptor superfamily member 1A
- Synonyms gene name:tumor necrosis factor receptor superfamily, member 1A
- Synonyms:TNF-RTNFARTNFR60TNF-R-ICD120aTNF-R55
- Discovery year:1991-01-15
- Entrez gene record:7132
- Pubmed identification:1655358, 2158863
- RefSeq identity:NM_001065
- Classification:Tumor necrosis factor receptor superfamily, CD molecules
- VEGA ID:OTTHUMG00000168267
- Identity:HGNC:11917
- Gene:TNFRSF1B
- Long gene name:TNF receptor superfamily member 1B
- Synonyms gene name:tumor necrosis factor receptor superfamily, member 1B
- Synonyms:TNFBRTNFR80TNF-R75TNF-R-IIp75CD120b
- Discovery year:1991-01-15
- Entrez gene record:7133
- Pubmed identification:2158863, 8702885
- RefSeq identity:NM_001066
- Classification:CD molecules, MicroRNA protein coding host genes, Tumor necrosis factor receptor superfamily
- VEGA ID:OTTHUMG00000001829
- Gene symbolTNF, TNFRSF1A, TNFRSF1B, LTBR
- isotype filter
- Immunoglobulin G IgG
- LabelALEXA FLUOR 647
- label filter
- ALEXA FLUOR 647
- technique filter
- Antibody
- TechniqueAntibody, antibodies against human proteins, antibodies for
- Alternative techniqueantibodies