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HDAC6 Antibody, ALEXA FLUOR 488

  • Catalog number
    bs-2811R-A488
  • Product name
    HDAC6 Antibody, ALEXA FLUOR 488
  • Size
    100ul
  • Short name
    Anti-HDAC6
  • Long name
    HDAC6 Polyclonal Antibody, ALEXA FLUOR 488 Conjugated
  • Also known as
    Anti-HDAC6 PAb ALEXA FLUOR 488
  • Category
    Conjugated Primary Antibodies
  • Conjugated with
    ALEXA FLUOR® 488
  • Host Organism
    Rabbit (Oryctolagus cuniculus)
  • Target Antigen
    HDAC6
  • Specificity
    This is a highly specific antibody against HDAC6.
  • Modification
    Unmodified
  • Modification Site
    None
  • Clonality
    Polyclonal
  • Clone
    Polyclonal antibody
  • Isotype
    Immunoglobulin G (IgG)
  • Concentration
    1ug per 1ul
  • Immunogen range
    330-380/1215
  • Subcellular location
    Cytoplasm, Nucleus
  • Source
    This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human HDAC6
  • Gene ID Number
    10013
  • Swiss Prot
    Q9UBN7
  • Tested applications
    IF(IHC-P)
  • Recommended dilutions
    IF(IHC-P)(1:50-200)
  • Crossreactivity
    Human, Mouse, Rat
  • Cross reactive species details
    Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
  • Background of the antigen
    Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome. Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy.
  • Purification
    Purified by Protein A.
  • Storage conditions
    Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
  • Excitation emission
    499nm/519nm
  • Synonyms
    HD6; JM21; CPBHM; PPP1R90; Histone deacetylase 6; HDAC6; KIAA0901
  • Alternative to gene target
    • [ "histone deacetylase 6", "CPBHM and HD6 and PPP1R90", "HDAC6 and IDBG-63929 and ENSG00000094631 and 10013", "NAD-dependent histone deacetylase activity (H3-K18 specific)", "nuclei", "Hdac6 and IDBG-129835 and ENSMUSG00000031161 and 15185", "BT.76413 and IDBG-636881 and ENSBTAG00000013244 and 513602" ]
  • Gene target
    HDAC6
    • Gene info
    Locus Specific Databases:Global Variome shared LOVD
  • Gene symbol
    HDAC6
  • isotype filter
    • Immunoglobulin G IgG
  • Label
    ALEXA FLUOR 488
  • label filter
    • ALEXA FLUOR 488
  • technique filter
    • Antibody
  • Technique
    Antibody, antibodies against human proteins, antibodies for
  • Alternative technique
    antibodies