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EPO Receptor (Tyr368) Antibody, ALEXA FLUOR 647

  • Catalog number
    bs-13087R-A647
  • Product name
    EPO Receptor (Tyr368) Antibody, ALEXA FLUOR 647
  • Size
    100ul
  • Short name
    Anti-EPO Receptor Tyr368
  • Long name
    EPO Receptor (Tyr368) Antibody, ALEXA FLUOR 647 Conjugated
  • Also known as
    Anti-EPO Receptor Tyr368 PAb ALEXA FLUOR 647
  • Category
    Conjugated Primary Antibodies
  • Conjugated with
    ALEXA FLUOR® 647
  • Host Organism
    Rabbit (Oryctolagus cuniculus)
  • Target Antigen
    EPO Receptor Tyr368
  • Specificity
    This is a highly specific antibody against EPO Receptor Tyr368.
  • Modification
    Phosphorylation
  • Modification Site
    Tyr368
  • Clonality
    Polyclonal
  • Clone
    Polyclonal antibody
  • Isotype
    Immunoglobulin G (IgG)
  • Concentration
    1ug per 1ul
  • Source
    KLH conjugated synthetic phosphopeptide derived from human EPO Receptor around the phosphorylation site of Tyr368
  • Gene ID Number
    2057
  • Tested applications
    IF(IHC-P)
  • Recommended dilutions
    IF(IHC-P)(1:50-200)
  • Crossreactivity
    Human, Mouse, Rat
  • Cross reactive species details
    Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
  • Background of the antigen
    The erythropoietin receptor (EPOR) is a member of the cytokine receptor family. There are several isoforms including: EPOR-F (full length), EPOR-S (soluble form), and EPOR-T (truncated form). Upon erythropoietin (EPO) binding, the EPOR activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated EPOR appears to have a role in erythroid cell survival. Defects in the EPOR may produce erythroleukemia and familial erythrocytosis. A functional EPOR is found in the cardiovascular system, including endothelial cells and cardiomyocytes, and data suggest that the EPO/EPO receptor system plays an important role in cardiac function. In animal studies, treatment with EPO during ischemia/reperfusion in the heart has been shown to limit the infarct size and the extent of apoptosis.
  • Purification
    Purified by Protein A.
  • Storage conditions
    Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
  • Excitation emission
    650nm/665nm
  • Synonyms
    EPO Receptor phospho Y368; p-EPO Receptor phospho Y368; EPOR phospho Y368; p-EPOR phospho Y368; erythropoietin receptor; EPO R; EPO Receptor; Erythropoietin receptor precursor.
  • Alternative to gene target
    • [ "erythropoietin", "EP and MVCD2", "EPO and IDBG-31941 and ENSG00000130427 and 2056", "protein kinase activator activity", "Extracellular", "Epo and IDBG-205003 and ENSMUSG00000029711 and 13856", "EPO and IDBG-640493 and ENSBTAG00000003430 and 280784" ]
  • Gene target
    EPO Receptor Tyr368
    • Gene info
    Gene info
    Locus Specific Databases:Global Variome shared LOVD
    Gene info
  • Gene symbol
    EPO, TIMP1, EPX
  • isotype filter
    • Immunoglobulin G IgG
  • Label
    ALEXA FLUOR 647
  • label filter
    • ALEXA FLUOR 647
  • technique filter
    • Antibody
  • Technique
    Antibody, antibodies against human proteins, antibodies for
  • Alternative technique
    antibodies