gentaur logogentaur logo
x

BNIP3 (Ser95) Antibody, ALEXA FLUOR 647

  • Catalog number
    bs-12875R-A647
  • Product name
    BNIP3 (Ser95) Antibody, ALEXA FLUOR 647
  • Size
    100ul
  • Short name
    Anti-BNIP3 Ser95
  • Long name
    BNIP3 (Ser95) Polyclonal Antibody, ALEXA FLUOR 647 Conjugated
  • Also known as
    Anti-BNIP3 Ser95 PAb ALEXA FLUOR 647
  • Category
    Conjugated Primary Antibodies
  • Conjugated with
    ALEXA FLUOR® 647
  • Host Organism
    Rabbit (Oryctolagus cuniculus)
  • Target Antigen
    BNIP3 Ser95
  • Specificity
    This is a highly specific antibody against BNIP3 Ser95.
  • Modification
    Phosphorylation
  • Modification Site
    Ser95
  • Clonality
    Polyclonal
  • Clone
    Polyclonal antibody
  • Isotype
    Immunoglobulin G (IgG)
  • Concentration
    1ug per 1ul
  • Source
    KLH conjugated synthetic phosphopeptide derived from human BNIP3 around the phosphorylation site of Ser95
  • Gene ID Number
    664
  • Tested applications
    IF(IHC-P)
  • Recommended dilutions
    IF(IHC-P)(1:50-200)
  • Crossreactivity
    Human
  • Cross reactive species details
    Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
  • Background of the antigen
    The adenovirus E1B protein is a viral homolog of the Bcl-2 family of proteins that are involved in regulating cell death. A family of interacting proteins, which are designated Nip or Bnip and include BNIP-1, BNIP-2, BNIP-3 and Nix, associate with both the E1B protein and Bcl-2 proteins to mediate apoptotic signaling. BNIP-1 contains a hydrophobic transmembrane domain, which enables its localization to the nuclear envelope, endoplasmic recticulum and mitochondria. BNIP-2, (previously designated Nip2 and Nip21 in human and mouse respectively), shares homology with the non-catalytic domain of Cdc42 GTPase-activating protein (Cdc42GAP). Through binding to Cdc42GAP, BNIP-2 enhances the GTPase activity of Cdc42GAP, facilitating the hydrolysis of GTP bound to Cdc42 and thereby, mediating the signaling pathways involving receptor kinases, small GTPases and apoptotic proteins. Nix, which is also designated Nip3L or Bnip3L, is highly related to BNIP-3, and both proteins localize to the mitochondria where they associate with Bcl-2 proteins. BNIP-3 preferentially binds to Bcl-xL and induces apoptosis by suppressing the anti-apoptosis activity of Bcl-xL.
  • Purification
    Purified by Protein A.
  • Storage conditions
    Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
  • Excitation emission
    650nm/665nm
  • Synonyms
    BNIP3 phospho S95; p-BNIP3 phospho S95; BCL2 Adenovirus E1B 19kDa Interacting Protein 3; BCL2/adenovirus E1B 19 kDa protein interacting protein 3; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3; BNIP 3; BNIP3; BNIP3_HUMAN; NIP 3; NIP3.
  • Alternative to gene target
    • [ "BCL2/adenovirus E1B 19kDa interacting protein 3", "NIP3", "BNIP3 and IDBG-93314 and ENSG00000176171 and 664", "GTPase binding", "nuclei", "Bnip3 and IDBG-269444 and ENSMUSG00000078566 and 12176", "BNIP3 and IDBG-641206 and ENSBTAG00000017804 and 615342" ]
  • Gene target
    BNIP3 Ser95
    • Gene info
  • Gene symbol
    BNIP3
  • isotype filter
    • Immunoglobulin G IgG
  • Label
    ALEXA FLUOR 647
  • label filter
    • ALEXA FLUOR 647
  • technique filter
    • Antibody
  • Technique
    Antibody, antibodies against human proteins, antibodies for
  • Alternative technique
    antibodies