- Catalog numberbs-12481R-A594
- Product nameAPC (Ser2054) Antibody, ALEXA FLUOR 594
- Size100ul
- PriceAsk For Price
- Short nameAnti-APC Ser2054
- Long nameAPC (Ser2054) Polyclonal Antibody, ALEXA FLUOR 594 Conjugated
- Also known asAnti-APC Ser2054 PAb ALEXA FLUOR 594
- CategoryConjugated Primary Antibodies
- Conjugated withALEXA FLUOR® 594
- Host OrganismRabbit (Oryctolagus cuniculus)
- Target AntigenAPC Ser2054
- SpecificityThis is a highly specific antibody against APC Ser2054.
- ModificationPhosphorylation
- Modification SiteSer2054
- ClonalityPolyclonal
- ClonePolyclonal antibody
- IsotypeImmunoglobulin G (IgG)
- Concentration1ug per 1ul
- SourceKLH conjugated synthetic phosphopeptide derived from human APC around the phosphorylation site of Ser2054
- Gene ID Number324
- Tested applicationsIF(IHC-P)
- Recommended dilutionsIF(IHC-P)(1:50-200)
- CrossreactivityHuman
- Cross reactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
- Background of the antigenTumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.
- PurificationPurified by Protein A.
- Storage conditionsStore this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
- Excitation emission590nm/617nm
- SynonymsAPC phospho S2054; p-APC phospho S2054; Adenomatous Polyposis Coli; APC; CC1; DP2; DP2.5; DP3; FAP; FPC; GS; Protein APC.
- Alternative to gene target
- [ "adenomatous polyposis coli", "BTPS2 and DP2 and DP2.5 and DP3 and GS and PPP1R46", "APC and IDBG-37007 and ENSG00000134982 and 324", "microtubule plus-end binding", "nuclei", "Apc and IDBG-134573 and ENSMUSG00000005871 and 11789", "BT.25770 and IDBG-644937 and ENSBTAG00000018852 and 533233" ]
- Gene targetAPC Ser2054
- Identity:HGNC:583
- Gene:APC
- Long gene name:APC regulator of WNT signaling pathway
- Synonyms gene name:adenomatosis polyposis coli, adenomatous polyposis coli, APC, WNT signaling pathway regulator
- Synonyms:DP2, DP3, DP2.5PPP1R46
- Discovery year:1986-01-01
- Entrez gene record:324
- Pubmed identification:1651563
- RefSeq identity:NM_000038
- Classification:Protein phosphatase 1 regulatory subunits, Armadillo repeat containing
- VEGA ID:OTTHUMG00000128806
- Gene symbolAPC
- isotype filter
- Immunoglobulin G IgG
- LabelAPC
- label filter
- APC
- technique filter
- Antibody
- TechniqueAntibody, antibodies against human proteins, antibodies for
- Alternative techniqueantibodies